Results 11 to 20 of about 104,139 (265)

The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor

eLife, 2014
Innate lymphoid cells (ILCs) are recently identified lymphocytes that limit infection and promote tissue repair at mucosal surfaces. However, the pathways underlying ILC development remain unclear. Here we show that the transcription factor NFIL3 directs
Xiaofei Yu, Yuhao Wang, Mi Deng, Yun Li, Kelly A Ruhn, Cheng Cheng Zhang, Lora V Hooper   +6 more
doaj   +1 more source

GATA2 haploinsufficient patients lack innate lymphoid cells that arise after hematopoietic cell transplantation

Frontiers in Immunology, 2022
Innate lymphoid cells (ILC) are important barrier tissue immune regulators. They play a pivotal role in early non-specific protection against infiltrating pathogens, regulation of epithelial integrity, suppression of pro-inflammatory immune responses and
Y. F. van Lier, Y. F. van Lier, L. Krabbendam, N. J. E. Haverkate, S. S. Zeerleder, C. E. Rutten, B. Blom, H. Spits, M. D. Hazenberg, M. D. Hazenberg, M. D. Hazenberg   +10 more
doaj   +1 more source

Effect of combining glucocorticoids with Compound A on glucocorticoid receptor responsiveness in lymphoid malignancies [PDF]

, 2018
Glucocorticoids (GCs) are a cornerstone in the treatment of lymphoid malignancies such as multiple myeloma (MM) and acute lymphoblastic leukemia (ALL).
Beck, Ilse, Clarisse, Dorien, De Bosscher, Karolien, Offner, Fritz, Tavernier, Jan, Van Wesemael, Karlien   +5 more
core   +10 more sources

Growth of donor-derived dendritic cells from the bone marrow of murine liver auograft recipients in response to granulocyte/macrophage colony-stimulating factor [PDF]

, 1995
Allografts of the liver, which has a comparatively heavy leukocyte content compared with other vascularized organs, are accepted permanently across major histocompatibility complex barriers in many murine strain combinations without immunosuppressive ...
Fu, F, Fung, JJ, Lu, L, McCaslin, D, Qian, S, Rao, AS, Rudert, WA, Starzl, TE, Thomson, AW, Trucco, M   +9 more
core   +1 more source

Gene Correction of iPSCs from a Wiskott-Aldrich Syndrome Patient Normalizes the Lymphoid Developmental and Functional Defects

Stem Cell Reports, 2016
Wiskott-Aldrich syndrome (WAS) is an X-linked primary immunodeficiency disease caused by mutations in the gene encoding the WAS protein (WASp). Here, induced pluripotent stem cells (iPSCs) were derived from a WAS patient (WAS-iPSC) and the endogenous ...
Tamara J. Laskowski, Yasmine Van Caeneghem, Rasoul Pourebrahim, Chao Ma, Zhenya Ni, Zita Garate, Ana M. Crane, Xuan Shirley Li, Wei Liao, Manuel Gonzalez-Garay, Jose Carlos Segovia, David E. Paschon, Edward J. Rebar, Michael C. Holmes, Dan Kaufman, Bart Vandekerckhove, Brian R. Davis   +16 more
doaj   +1 more source

Dendritic cell subsets in the intestinal lamina propria: ontogeny and function [PDF]

, 2013
The intestinal mucosa is exposed to large amounts of foreign antigen (Ag) derived from commensal bacteria, dietary Ags, and intestinal pathogens. Dendritic cells (DCs) are believed to be involved in the induction of tolerance to harmless Ags and in ...
Agace, Agace, Agace, Aliberti, Anjuere, Annacker, Bachem, Bachem, Bain, Banchereau, Bedoui, Bogunovic, Carter, Cebula, Cerovic, Chervonsky, Coombes, Crozat, Cruickshank, del Rio, del Rio, Denning, Diehl, Edelson, Edelson, Farache, Forster, Fujimoto, Ginhoux, Greter, Hadis, Halle, Hammerschmidt, Haniffa, Hildner, Hoshi, Ichikawa, Iwata, Jackson, Jaensson, Jaensson-Gyllenback, Jang, Johansson-Lindbom, Johansson-Lindbom, Jones, Jongbloed, Kinnebrew, Kobayashi, Kusunoki, Lewis, Liu, Macpherson, Maynard, McDole, Merad, Miller, Milling, Molenaar, Mucida, Naik, Naik, Niess, Onai, Persson, Poulin, Poulin, Rescigno, Rivollier, Sathaliyawala, Schlitzer, Schulz, Scott, Siddiqui, Sun, Svensson, Tamoutounour, Travis, Uematsu, Uematsu, Vallon-Eberhard, Varol, Vremec, Weiss, Worbs, Wu, Zeng, Zhan, Zigmond   +87 more
core   +1 more source

Activation of the Arterial Program Drives Development of Definitive Hemogenic Endothelium with Lymphoid Potential

Cell Reports, 2018
Summary: Understanding the pathways guiding the development of definitive hematopoiesis with lymphoid potential is essential for advancing human pluripotent stem cell (hPSC) technologies for the treatment of blood diseases and immunotherapies.
Mi Ae Park, Akhilesh Kumar, Ho Sun Jung, Gene Uenishi, Oleg V. Moskvin, James A. Thomson, Igor I. Slukvin   +6 more
doaj   +1 more source

Ezrin is highly expressed in early thymocytes, but dispensable for T cell development in mice.

PLoS ONE, 2010
BackgroundEzrin/radixin/moesin (ERM) proteins are highly homologous proteins that function to link cargo molecules to the actin cytoskeleton. Ezrin and moesin are both expressed in mature lymphocytes, where they play overlapping roles in cell signaling ...
Meredith H Shaffer, Yanping Huang, Evann Corbo, Gregory F Wu, Marielena Velez, John K Choi, Ichiko Saotome, Judy L Cannon, Andrea I McClatchey, Anne I Sperling, Jonathan S Maltzman, Paula M Oliver, Avinash Bhandoola, Terri M Laufer, Janis K Burkhardt   +14 more
doaj   +1 more source

Batf3-dependent CD11b(low/-) peripheral dendritic cells are GM-CSF-independent and are not required for Th cell priming after subcutaneous immunization. [PDF]

PLoS ONE, 2011
Dendritic cells (DCs) subsets differ in precursor cell of origin, functional properties, requirements for growth factors, and dependence on transcription factors.
Brian T Edelson, Tara R Bradstreet, Wumesh KC, Kai Hildner, Jeremy W Herzog, Julia Sim, John H Russell, Theresa L Murphy, Emil R Unanue, Kenneth M Murphy   +9 more
doaj   +1 more source

Regulated progression of B lymphocyte differentiation from cultured fetal liver. [PDF]

, 1987
Lymphoid fetal liver cultures (LFLC) are long-term, nontransformed cultures of early B lymphoid lineage cells which appear developmentally blocked at the pre-B stage in vitro.
Denis, KA, Dorshkind, K, Witte, ON
core   +2 more sources