Results 11 to 20 of about 14,408,725 (200)
Cancer management and research, 2019 Purpose: T-lymphoid/Myeloid Mixed phenotype acute leukemia (T/M-MPAL) is ambiguous leukemia which overlaps with early T-cell precursor lymphoblastic leukemia (ETP-ALL). We have revisited the immunophenotyping profile of T/M-MPAL and ETP-ALL to identify differences and/or similarities, as these entities represent a therapeutic challenge in clinical ...
Noronha,Elda Pereira +7 more
openaire +5 more sources
In situ characterisation of CD4+ t cell behaviour in mucosal and systemic lymphoid tissues during the induction of oral priming and tolerance [PDF]
, 2005 The behavior of antigen-specific CD4+ T lymphocytes during initial exposure to antigen probably influences their decision to become primed or tolerized, but this has not been examined directly in vivo.
Cahalan, M. +12 more
core +4 more sources
Simulation and Statistical Techniques to Explore Lymphoid Tissue Organogenesis [PDF]
, 2012 Secondary lymphoid organs have a key role in the initiation of adaptive immune responses to infection. Organogenesis occurs in foetal development, and the use of genetic tools, imaging technologies, and ex vivo culture systems has provided significant ...
Alden, Kieran
core +6 more sources
Impaired Development of T Lymphoid Precursors from Pluripotent Hematopoietic Stem Cells in New Zealand Black Mice [PDF]
The Journal of Immunology, 2002 Abstract Bone marrow cells from autoimmune-prone New Zealand Black (NZB) mice are less efficient at colonizing fetal thymic lobes than cells from normal strains. This study demonstrates that the reduced capacity of NZB bone marrow cells to repopulate the thymus does not result from their inability to migrate to or enter the thymus ...
Yoshiko, Hashimoto +3 more
openaire +2 more sources
Ageing compromises mouse thymus function and remodels epithelial cell differentiation
eLife, 2020 Ageing is characterised by cellular senescence, leading to imbalanced tissue maintenance, cell death and compromised organ function. This is first observed in the thymus, the primary lymphoid organ that generates and selects T cells.
Jeanette Baran-Gale +17 more
doaj +1 more source
FOXO3 regulates CD8 T cell memory by T cell-intrinsic mechanisms. [PDF]
PLoS Pathogens, 2012 CD8 T cell responses have three phases: expansion, contraction, and memory. Dynamic alterations in proliferation and apoptotic rates control CD8 T cell numbers at each phase, which in turn dictate the magnitude of CD8 T cell memory.
Jeremy A Sullivan +4 more
doaj +1 more source
F1000Research, 2017 CD4+ T cells provide a neuro-immunological link in the regulation of adult hippocampal neurogenesis, but the exact mechanisms underlying enhanced neural precursor cell proliferation and the relative contribution of different T helper (Th) cell subsets ...
Johannes Niebling +4 more
doaj +1 more source
Characterization of lymphoid tissue inducer cells and lymphoid tissue development in adult interleukin 7 transgenic mice [PDF]
, 2008 During embryogenesis, the development of secondary lymphoid organs (SLOs) such as lymph nodes (LNs) and Peyer’s patches (PPs) requires the cellular crosstalk between vascular cell adhesion molecule (VCAM)-1+ mesenchymal organizer cells and CD45+CD4 ...
Schmutz, Sandrine
core +1 more source
F1000Research, 2014 CD4+ T cells provide a neuro-immunological link in the regulation of adult hippocampal neurogenesis, but the exact mechanisms underlying enhanced neural precursor cell proliferation and the relative contribution of different T helper (Th) cell subsets ...
Johannes Niebling +4 more
doaj +1 more source
Intrathymic lymphoid precursor cells during fetal thymus development.
Journal of Immunology, 1993 Our previous studies have demonstrated the presence, in the adult mouse thymus, of a population of early precursor cells able to give rise to T and B lymphocytes but not myeloid cells.
M. Antica +3 more
semanticscholar +1 more source