Results 11 to 20 of about 58,276 (219)

Gene Correction of iPSCs from a Wiskott-Aldrich Syndrome Patient Normalizes the Lymphoid Developmental and Functional Defects

Stem Cell Reports, 2016
Wiskott-Aldrich syndrome (WAS) is an X-linked primary immunodeficiency disease caused by mutations in the gene encoding the WAS protein (WASp). Here, induced pluripotent stem cells (iPSCs) were derived from a WAS patient (WAS-iPSC) and the endogenous ...
Tamara J. Laskowski, Yasmine Van Caeneghem, Rasoul Pourebrahim, Chao Ma, Zhenya Ni, Zita Garate, Ana M. Crane, Xuan Shirley Li, Wei Liao, Manuel Gonzalez-Garay, Jose Carlos Segovia, David E. Paschon, Edward J. Rebar, Michael C. Holmes, Dan Kaufman, Bart Vandekerckhove, Brian R. Davis   +16 more
doaj   +1 more source

Activation of the Arterial Program Drives Development of Definitive Hemogenic Endothelium with Lymphoid Potential

Cell Reports, 2018
Summary: Understanding the pathways guiding the development of definitive hematopoiesis with lymphoid potential is essential for advancing human pluripotent stem cell (hPSC) technologies for the treatment of blood diseases and immunotherapies.
Mi Ae Park, Akhilesh Kumar, Ho Sun Jung, Gene Uenishi, Oleg V. Moskvin, James A. Thomson, Igor I. Slukvin   +6 more
doaj   +1 more source

Ezrin is highly expressed in early thymocytes, but dispensable for T cell development in mice.

PLoS ONE, 2010
BackgroundEzrin/radixin/moesin (ERM) proteins are highly homologous proteins that function to link cargo molecules to the actin cytoskeleton. Ezrin and moesin are both expressed in mature lymphocytes, where they play overlapping roles in cell signaling ...
Meredith H Shaffer, Yanping Huang, Evann Corbo, Gregory F Wu, Marielena Velez, John K Choi, Ichiko Saotome, Judy L Cannon, Andrea I McClatchey, Anne I Sperling, Jonathan S Maltzman, Paula M Oliver, Avinash Bhandoola, Terri M Laufer, Janis K Burkhardt   +14 more
doaj   +1 more source

Derivation and Differentiation of Adipose-Tissue Regulatory T Cells: A Stepwise, Multi-Site Process

Frontiers in Immunology, 2020
CD4+ Foxp3+ regulatory T cells (Tregs) not only enforce peripheral tolerance and restrain self-reactive immune responses, but also maintain organismal homeostasis and safeguard the function of parenchymal tissues.
Pulavendran Sivasami, Chaoran Li
doaj   +1 more source

Batf3-dependent CD11b(low/-) peripheral dendritic cells are GM-CSF-independent and are not required for Th cell priming after subcutaneous immunization. [PDF]

PLoS ONE, 2011
Dendritic cells (DCs) subsets differ in precursor cell of origin, functional properties, requirements for growth factors, and dependence on transcription factors.
Brian T Edelson, Tara R Bradstreet, Wumesh KC, Kai Hildner, Jeremy W Herzog, Julia Sim, John H Russell, Theresa L Murphy, Emil R Unanue, Kenneth M Murphy   +9 more
doaj   +1 more source

High-mobility group box (TOX) antibody a useful tool for the identification of B and T cell subpopulations.

PLoS ONE, 2020
Thymocyte selection-associated high-mobility group box (TOX) is a DNA-binding factor that is able to regulate transcription by modifying local chromatin structure and modulating the formation of multi-protein complexes.
Lorena Maestre, Juan Fernando García-García, Scherezade Jiménez, Ana Isabel Reyes-García, Álvaro García-González, Santiago Montes-Moreno, Alberto J Arribas, Patricia González-García, Eduardo Caleiras, Alison H Banham, Miguel Ángel Piris, Giovanna Roncador   +11 more
doaj   +1 more source

Comparative study of hematopoietic differentiation between human embryonic stem cell lines. [PDF]

PLoS ONE, 2011
Directed differentiation of human embryonic stem cells (hESCs) into any desired cell type has been hailed as a therapeutic promise to cure many human diseases.
Heather Melichar, Ou Li, Jenny Ross, Hilary Haber, Dragana Cado, Hector Nolla, Ellen A Robey, Astar Winoto   +7 more
doaj   +1 more source

T-BET and EOMES sustain mature human NK cell identity and antitumor function

The Journal of Clinical Investigation, 2023
Since the T-box transcription factors (TFs) T-BET and EOMES are necessary for initiation of NK cell development, their ongoing requirement for mature NK cell homeostasis, function, and molecular programming remains unclear.
Pamela Wong, Jennifer A. Foltz, Lily Chang, Carly C. Neal, Tony Yao, Celia C. Cubitt, Jennifer Tran, Samantha Kersting-Schadek, Sathvik Palakurty, Natalia Jaeger, David A. Russler-Germain, Nancy D. Marin, Margery Gang, Julia A. Wagner, Alice Y. Zhou, Miriam T. Jacobs, Mark Foster, Timothy Schappe, Lynne Marsala, Ethan McClain, Patrick Pence, Michelle Becker-Hapak, Bryan Fisk, Allegra A. Petti, Obi L. Griffith, Malachi Griffith, Melissa M. Berrien-Elliott, Todd A. Fehniger   +27 more
doaj   +1 more source

An unusual presentation of precursor T cell lymphoblastic leukemia/lymphoma with cholestatic jaundice: case report

Journal of Hematology & Oncology, 2009
Background Cholestatic jaundice as a presenting symptom of Precursor T-lymphoblastic leukemia (T-ALL)/lymphoma (T-LBL) has never been reported in literature. Similarly, precursor T-ALL/T-LBL is characteristically negative for synaptophysin. We report the
Latif Sahibzada U, Patel Kevin J, de Calaca Wanderley M   +2 more
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Multi-modular structure of the gene regulatory network for specification and commitment of murine T cells

Frontiers in Immunology, 2023
T cells develop from multipotent progenitors by a gradual process dependent on intrathymic Notch signaling and coupled with extensive proliferation. The stages leading them to T-cell lineage commitment are well characterized by single-cell and bulk RNA ...
Boyoung Shin, Ellen V. Rothenberg
doaj   +1 more source