Results 1 to 10 of about 104,139 (265)
Cancer management and research, 2019 Purpose: T-lymphoid/Myeloid Mixed phenotype acute leukemia (T/M-MPAL) is ambiguous leukemia which overlaps with early T-cell precursor lymphoblastic leukemia (ETP-ALL). We have revisited the immunophenotyping profile of T/M-MPAL and ETP-ALL to identify differences and/or similarities, as these entities represent a therapeutic challenge in clinical ...
Noronha,Elda Pereira +7 more
openaire +5 more sources
Impaired Development of T Lymphoid Precursors from Pluripotent Hematopoietic Stem Cells in New Zealand Black Mice [PDF]
The Journal of Immunology, 2002 Abstract Bone marrow cells from autoimmune-prone New Zealand Black (NZB) mice are less efficient at colonizing fetal thymic lobes than cells from normal strains. This study demonstrates that the reduced capacity of NZB bone marrow cells to repopulate the thymus does not result from their inability to migrate to or enter the thymus ...
Yoshiko, Hashimoto +3 more
openaire +2 more sources
The Ews-ERG fusion protein can initiate neoplasia from lineage-committed haematopoietic cells. [PDF]
PLoS Biology, 2005 The EWS-ERG fusion protein is found in human sarcomas with the chromosomal translocation t(21;22)(q22;q12), where the translocation is considered to be an initiating event in sarcoma formation within uncommitted mesenchymal cells, probably long-lived ...
Rosalind Codrington +7 more
doaj +2 more sources
A disconnect between precursor frequency, expansion potential, and site-specific CD4+ T cell responses in aged mice. [PDF]
PLoS ONE, 2018 T cell recognition of peptides presented within self-major histocompatibility complex (pMHC) molecules is essential for long-lived protective immunity. As mice age the number of naïve CD4+ and CD8+ T cells declines.
Neha R Deshpande +4 more
doaj +1 more source
Ageing compromises mouse thymus function and remodels epithelial cell differentiation
eLife, 2020 Ageing is characterised by cellular senescence, leading to imbalanced tissue maintenance, cell death and compromised organ function. This is first observed in the thymus, the primary lymphoid organ that generates and selects T cells.
Jeanette Baran-Gale +17 more
doaj +1 more source
FOXO3 regulates CD8 T cell memory by T cell-intrinsic mechanisms. [PDF]
PLoS Pathogens, 2012 CD8 T cell responses have three phases: expansion, contraction, and memory. Dynamic alterations in proliferation and apoptotic rates control CD8 T cell numbers at each phase, which in turn dictate the magnitude of CD8 T cell memory.
Jeremy A Sullivan +4 more
doaj +1 more source
F1000Research, 2017 CD4+ T cells provide a neuro-immunological link in the regulation of adult hippocampal neurogenesis, but the exact mechanisms underlying enhanced neural precursor cell proliferation and the relative contribution of different T helper (Th) cell subsets ...
Johannes Niebling +4 more
doaj +1 more source
Zebrafish Caudal Haematopoietic Embryonic Stromal Tissue (CHEST) Cells Support Haematopoiesis. [PDF]
, 2017 Haematopoiesis is an essential process in early vertebrate development that occurs in different distinct spatial locations in the embryo that shift over time.
Aggio, Julian +6 more
core +1 more source
F1000Research, 2014 CD4+ T cells provide a neuro-immunological link in the regulation of adult hippocampal neurogenesis, but the exact mechanisms underlying enhanced neural precursor cell proliferation and the relative contribution of different T helper (Th) cell subsets ...
Johannes Niebling +4 more
doaj +1 more source
Benign TdT-positive cells in pediatric and adult lymph nodes: a potential diagnostic pitfall [PDF]
, 2018 Benign TdT-positive cells have been documented in a variety of non-hematopoietic tissues. Scant data are however available on their presence in non-neoplastic lymph nodes.
AGOSTINELLI, CLAUDIO +8 more
core +1 more source