Results 1 to 10 of about 161,735 (159)
eLife, 2014 Innate lymphoid cells (ILCs) are recently identified lymphocytes that limit infection and promote tissue repair at mucosal surfaces. However, the pathways underlying ILC development remain unclear. Here we show that the transcription factor NFIL3 directs
Xiaofei Yu +6 more
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Lymphoid reconstitution of the human fetal thymus in SCID mice with CD34+ precursor cells.
Journal of Experimental Medicine, 1991 The search for human hematopoietic stem cells has been hampered by the lack of appropriate assay systems. Demonstration of the ability of precursor cell candidates to give rise to T cells is of significant difficulty since dissociated in vitro cultured ...
Irving Weissman +2 more
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Nature CommunicationsDespite the success of immune checkpoint blockade (ICB) therapy for esophageal squamous cell cancer, the key immune cell populations that affect ICB efficacy remain unclear.
Kenro Tanoue +22 more
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Human Innate Lymphoid Cells: Their Functional and Cellular Interactions in Decidua
Frontiers in Immunology, 2018 Innate lymphoid cells (ILC) are developmentally related cell subsets that play a major role in innate defenses against pathogens, in lymphoid organogenesis and in tissue remodeling. The best characterized ILC are natural killer (NK) cells.
Paola Vacca +9 more
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Cell Reports, 2018 Summary: Understanding the pathways guiding the development of definitive hematopoiesis with lymphoid potential is essential for advancing human pluripotent stem cell (hPSC) technologies for the treatment of blood diseases and immunotherapies.
Mi Ae Park +6 more
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Spatially-resolved pharmaco-ecology of immunotherapy resistance in lung adenocarcinoma: Single-cell and spatial transcriptomics for mechanism-matched combination therapies [PDF]
Translational OncologyImmune checkpoint inhibitors have reshaped the treatment landscape of lung adenocarcinoma, but primary, adaptive and acquired resistance are still the main clinical obstacles.
Yiming Hua, Zhanyang Luo, Zhimei Huang
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The precursors of CD8+ tissue resident memory T cells: from lymphoid organs to infected tissues
Nature reviews. Immunology, 2021 CD8+ tissue resident memory T cells (TRM cells) are essential for immune defence against pathogens and malignancies, and the molecular processes that lead to TRM cell formation are therefore of substantial biomedical interest. Prior work has demonstrated
Lianne Kok, D. Masopust, T. Schumacher
semanticscholar +1 more source
The Ews-ERG fusion protein can initiate neoplasia from lineage-committed haematopoietic cells. [PDF]
PLoS Biology, 2005 The EWS-ERG fusion protein is found in human sarcomas with the chromosomal translocation t(21;22)(q22;q12), where the translocation is considered to be an initiating event in sarcoma formation within uncommitted mesenchymal cells, probably long-lived ...
Rosalind Codrington +7 more
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A disconnect between precursor frequency, expansion potential, and site-specific CD4+ T cell responses in aged mice. [PDF]
PLoS ONE, 2018 T cell recognition of peptides presented within self-major histocompatibility complex (pMHC) molecules is essential for long-lived protective immunity. As mice age the number of naïve CD4+ and CD8+ T cells declines.
Neha R Deshpande +4 more
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Immunity, 2020 Summary Specialized regulatory T (Treg) cells accumulate and perform homeostatic and regenerative functions in nonlymphoid tissues. Whether common precursors for nonlymphoid-tissue Treg cells exist and how they differentiate remain elusive.
M. Delacher +22 more
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