Results 21 to 30 of about 104,139 (265)
Derivation and Differentiation of Adipose-Tissue Regulatory T Cells: A Stepwise, Multi-Site Process
Frontiers in Immunology, 2020 CD4+ Foxp3+ regulatory T cells (Tregs) not only enforce peripheral tolerance and restrain self-reactive immune responses, but also maintain organismal homeostasis and safeguard the function of parenchymal tissues.
Pulavendran Sivasami, Chaoran Li
doaj +1 more source
Comparative study of hematopoietic differentiation between human embryonic stem cell lines. [PDF]
PLoS ONE, 2011 Directed differentiation of human embryonic stem cells (hESCs) into any desired cell type has been hailed as a therapeutic promise to cure many human diseases.
Heather Melichar +7 more
doaj +1 more source
PLoS ONE, 2020 Thymocyte selection-associated high-mobility group box (TOX) is a DNA-binding factor that is able to regulate transcription by modifying local chromatin structure and modulating the formation of multi-protein complexes.
Lorena Maestre +11 more
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T-BET and EOMES sustain mature human NK cell identity and antitumor function
The Journal of Clinical Investigation, 2023 Since the T-box transcription factors (TFs) T-BET and EOMES are necessary for initiation of NK cell development, their ongoing requirement for mature NK cell homeostasis, function, and molecular programming remains unclear.
Pamela Wong +27 more
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Subset- and tissue-defined STAT5 thresholds control homeostasis and function of innate lymphoid cells [PDF]
, 2016 Innate lymphoid cells (ILCs) patrol environmental interfaces to defend against infection and protect barrier integrity. Using a genetic tuning model, we demonstrate that the signal-dependent transcription factor (TF) STAT5 is critical for accumulation of
Villarino, Alejandro V^ +9 more
core +1 more source
Journal of Hematology & Oncology, 2009 Background Cholestatic jaundice as a presenting symptom of Precursor T-lymphoblastic leukemia (T-ALL)/lymphoma (T-LBL) has never been reported in literature. Similarly, precursor T-ALL/T-LBL is characteristically negative for synaptophysin. We report the
Latif Sahibzada U +2 more
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Frontiers in Immunology, 2023 T cells develop from multipotent progenitors by a gradual process dependent on intrathymic Notch signaling and coupled with extensive proliferation. The stages leading them to T-cell lineage commitment are well characterized by single-cell and bulk RNA ...
Boyoung Shin, Ellen V. Rothenberg
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KITD816V+ systemic mastocytosis associated with KITD816V+ acute erythroid leukaemia: first case report with molecular evidence for same progenitor cell derivation [PDF]
, 2009 Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE ...
H-P Horny +4 more
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Clec9a-mediated ablation of conventional dendritic cells suggests a lymphoid path to generating dendritic cells In Vivo [PDF]
, 2018 Conventional dendritic cells (cDCs) are versatile activators of immune responses that develop as part of the myeloid lineage downstream of hematopoietic stem cells.
Keppler, SJ +10 more
core +1 more source
NK Cell Precursors in Human Bone Marrow in Health and Inflammation
Frontiers in Immunology, 2019 NK cells are generated from hematopoietic stem cells (HSC) residing in the bone marrow (BM), similar to other blood cells. Development toward mature NK cells occurs largely outside the BM through travel of CD34+ and other progenitor intermediates toward ...
Federica Bozzano +5 more
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