Results 21 to 30 of about 14,408,725 (200)

GATA2 haploinsufficient patients lack innate lymphoid cells that arise after hematopoietic cell transplantation

Frontiers in Immunology, 2022
Innate lymphoid cells (ILC) are important barrier tissue immune regulators. They play a pivotal role in early non-specific protection against infiltrating pathogens, regulation of epithelial integrity, suppression of pro-inflammatory immune responses and
Y. F. van Lier, Y. F. van Lier, L. Krabbendam, N. J. E. Haverkate, S. S. Zeerleder, C. E. Rutten, B. Blom, H. Spits, M. D. Hazenberg, M. D. Hazenberg, M. D. Hazenberg   +10 more
doaj   +1 more source

Gene Correction of iPSCs from a Wiskott-Aldrich Syndrome Patient Normalizes the Lymphoid Developmental and Functional Defects

Stem Cell Reports, 2016
Wiskott-Aldrich syndrome (WAS) is an X-linked primary immunodeficiency disease caused by mutations in the gene encoding the WAS protein (WASp). Here, induced pluripotent stem cells (iPSCs) were derived from a WAS patient (WAS-iPSC) and the endogenous ...
Tamara J. Laskowski, Yasmine Van Caeneghem, Rasoul Pourebrahim, Chao Ma, Zhenya Ni, Zita Garate, Ana M. Crane, Xuan Shirley Li, Wei Liao, Manuel Gonzalez-Garay, Jose Carlos Segovia, David E. Paschon, Edward J. Rebar, Michael C. Holmes, Dan Kaufman, Bart Vandekerckhove, Brian R. Davis   +16 more
doaj   +1 more source

A committed hemopoietic precursor to innate lymphoid cells

Nature, 2014
Innate lymphoid cells (ILCs) specialize in the rapid secretion of polarized sets of cytokines and chemokines to combat infection and promote tissue repair at mucosal barriers. Their diversity and similarities with previously characterized natural killer (
Michael G. Constantinides, Benjamin D. McDonald, P. Verhoef, A. Bendelac   +3 more
semanticscholar   +1 more source

Ezrin is highly expressed in early thymocytes, but dispensable for T cell development in mice.

PLoS ONE, 2010
BackgroundEzrin/radixin/moesin (ERM) proteins are highly homologous proteins that function to link cargo molecules to the actin cytoskeleton. Ezrin and moesin are both expressed in mature lymphocytes, where they play overlapping roles in cell signaling ...
Meredith H Shaffer, Yanping Huang, Evann Corbo, Gregory F Wu, Marielena Velez, John K Choi, Ichiko Saotome, Judy L Cannon, Andrea I McClatchey, Anne I Sperling, Jonathan S Maltzman, Paula M Oliver, Avinash Bhandoola, Terri M Laufer, Janis K Burkhardt   +14 more
doaj   +1 more source

Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation [PDF]

, 2009
We show that Indian Hedgehog (Ihh) regulates T-cell development and homeostasis in both fetal and adult thymus, controlling thymocyte number. Fetal Ihh-/- thymi had reduced differentiation to double-positive (DP) cell and reduced cell numbers compared ...
Outram, Susan V, Ross, Susan E, Rowbotham, Nicola J, Crompton, T, Hager-Theodorides, Ariadne L, Shah, DK, Shah, Divya K, Drakopoulou, Ekati, Lanske, Beate, Crompton, Tessa, Dessens, Johannes T, Drakopoulou, E, Rowbotham, NJ, Dessens, JT, Ross, SE, Lanske, B, Outram, SV, Hager-Theodorides, AL   +17 more
core   +1 more source

Distribution of T-lymphocyte subsets in porcine lymphoid tissues [PDF]

, 1987
The distribution of the functional subsets of porcine T cells, the cytolytic/suppressor (Tc/s) and the helper/inducer (Th/i) cells was studied in cryostat sections of thymus, lymph nodes, tonsils, Peyer's patches, spleen and liver using the indirect ...
Saalmüller, Armin, Reddehase, Matthias J., Koszinowski, Ulrich H., Jonjic, Stipan, Bühring, Hans-Jörg   +4 more
core   +1 more source

Derivation and Differentiation of Adipose-Tissue Regulatory T Cells: A Stepwise, Multi-Site Process

Frontiers in Immunology, 2020
CD4+ Foxp3+ regulatory T cells (Tregs) not only enforce peripheral tolerance and restrain self-reactive immune responses, but also maintain organismal homeostasis and safeguard the function of parenchymal tissues.
Pulavendran Sivasami, Chaoran Li
doaj   +1 more source

Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumors

Nature, 2017
Tissue-resident memory CD8+ T (TRM) cells are found at common sites of pathogen exposure, where they elicit rapid and robust protective immune responses.
J. Milner, Clara Toma, Bing-Fei Yu, Kai Zhang, K. Omilusik, Anthony T. Phan, Dapeng Wang, Adam J. Getzler, Toan Nguyen, Shane Crotty, Wei Wang, M. Pipkin, Ananda W. Goldrath   +12 more
semanticscholar   +1 more source

PrPCWD lymphoid cell targets in early and advanced chronic wasting disease of mule deer [PDF]

, 2002
Up to 15% of free-ranging mule deer in northeastern Colorado and southeastern Wyoming, USA, are afflicted with a prion disease, or transmissible spongiform encephalopathy (TSE), known as chronic wasting disease (CWD).
Keulen, L.J.M., van, van Keulen, L.J.M., Miller, M.W., Oesch, B., Hoover, E.A., Langeveld, J.P.M., Sigurdson, C.J., Barillas-Mury, C.   +7 more
core   +1 more source

High-mobility group box (TOX) antibody a useful tool for the identification of B and T cell subpopulations.

PLoS ONE, 2020
Thymocyte selection-associated high-mobility group box (TOX) is a DNA-binding factor that is able to regulate transcription by modifying local chromatin structure and modulating the formation of multi-protein complexes.
Lorena Maestre, Juan Fernando García-García, Scherezade Jiménez, Ana Isabel Reyes-García, Álvaro García-González, Santiago Montes-Moreno, Alberto J Arribas, Patricia González-García, Eduardo Caleiras, Alison H Banham, Miguel Ángel Piris, Giovanna Roncador   +11 more
doaj   +1 more source