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Early T-cell Precursor Acute Lymphoblastic Leukemia/Lymphoma
Discrete diagnostic subtypes of T lymphoblastic leukemia/lymphoma (T-cell acute lymphoblastic leukemia/lymphoma, T-ALL) have historically not been widely recognized. Recently, a novel subset with distinctive immunophenotypic, molecular, and clinical features has been proposed.
David R. Czuchlewski, Kathryn Foucar
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Early T-cell precursor lymphoblastic leukemia (ETP-ALL) has a unique immunophenotype with very early T-cell differentiation. The current study summarises the distinct clinicopathological aspects of ETP-ALL and compares them with non-ETP-ALL. Twenty-nine ETP-ALL and 191 non-ETP-ALL cases were retrieved between 2018 and 2021. A P value was determined for
Anurag Saha+4 more
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Abstract Introduction: Recently, early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) was identified as a subtype of T-cell ALL (T-ALL), with distinctive gene expression and cell marker profiles. Some reports revealed that ETP-ALL was associated with a high risk of remission induction failure and relapse.
Reiji Fukano+15 more
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The human BHLHB1 (basic domain, helix-loop-helix protein, class B, 1; also known as OLIG 2 ) was initially cloned by virtue of its activation in pre-T lymphoblastic lymphoma/leukemia (pre-T LBL) with a t(14; 21)(q11.2; q22).
Yingwei Lin, Ramona Deveney, P. Aplan
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Survival rates of children with relapsed/refractory (r/r) BCP-ALL remain unsatisfactory and little progress has been made in the past 2 decades. Similarly, relapse of childhood B-NHL is usually associated with an aggressive disease and poor outcomes ...
F. Bufalo+18 more
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To analyze the clinical characteristics, treatment, and prognosis of adult patients with early T-cell precursor acute lymphoblastic leukemia/lymphoma (ETP-ALL/LBL).Clinical data of 113 T lymphoblastic leukemia/lymphoma (T-ALL/LBL) patients from January 2006 to January 2019 were collected from three hematology research centers, including Peking ...
Zheng-Hua, Li+6 more
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Cancer Research, 2010
Abstract Overexpression of Myc oncogenes (c-Myc, N-Myc and L-Myc) is frequently found in a wide range of tumors. Although many reports have shown that Myc can directly induce tumors in mice models, the cell-of-origin of the Myc-induced tumor is still unclear.
Masanao Miwa+5 more
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Abstract Overexpression of Myc oncogenes (c-Myc, N-Myc and L-Myc) is frequently found in a wide range of tumors. Although many reports have shown that Myc can directly induce tumors in mice models, the cell-of-origin of the Myc-induced tumor is still unclear.
Masanao Miwa+5 more
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Leukemia and Lymphoma, 2021
Early T-cell precursor acute lymphoblastic leukemia (ETPALL) is a clinically distinct and highly aggressive subset of T-cell ALL [1]. It is characterized by an immunophenotype with reduced or absent expression of CD1a, CD5 and CD8 and presence of at ...
Sankalp Arora+3 more
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Early T-cell precursor acute lymphoblastic leukemia (ETPALL) is a clinically distinct and highly aggressive subset of T-cell ALL [1]. It is characterized by an immunophenotype with reduced or absent expression of CD1a, CD5 and CD8 and presence of at ...
Sankalp Arora+3 more
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Early T‐cell precursor acute lymphoblastic leukemia with Auer rods in mature granulocytes
International Journal of Laboratory Hematology, 2021Dear Editors, Early Tcell precursor acute lymphoblastic leukemia (ETPALL) is a subtype of Tcell acute lymphoblastic leukemia/lymphoma (TALL/ LBL), which accounts for approximately 12% and 17%– 32% of TALL/LBL in children and adults, respectively.13 ETP ...
Yanfang Wang+4 more
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Journal of pediatric hematology/oncology, 2021
In the context of an evolving understanding of early T-cell precursor (ETP) lymphoma and leukemia, we present a case of concurrent T-cell lymphoblastic lymphoma and ETP lymphoma in an adolescent female.
Charles Treinen+5 more
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In the context of an evolving understanding of early T-cell precursor (ETP) lymphoma and leukemia, we present a case of concurrent T-cell lymphoblastic lymphoma and ETP lymphoma in an adolescent female.
Charles Treinen+5 more
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