Results 191 to 200 of about 2,930 (277)

Enhanced Intracellular Stability and Translation Efficiency of mRNA Drugs by a 2‐arm mRNA Platform

Advanced Science, EarlyView.
We constructed a 2‐arm mRNA, characterized by a unique topology formed through the dimerization of two mRNA 3’ tails. The 2‐arm mRNA improves 3’ tail stability and resistance to nuclease degradation, resulting in an intracellular half‐life of up to 65 h. This method substantially enhances the translation capacity of mRNA drugs.
Xucong Teng, Jiahao Lin, Qiushuang Zhang, Xiangdong Zhang, Yicong Dai, Jinghong Li   +5 more
wiley   +1 more source

Patient Education Deficits and Medication Knowledge Gaps Among Post-Percutaneous Coronary Intervention Patients: A Cross-Sectional Study of Communication Quality and Adherence in Saudi Cardiac Care. [PDF]

Healthcare (Basel)
Aljuhani M, Almutairi AS, Almutairi RR, Alodhailah AM.   +3 more
europepmc   +1 more source

DNA Nanoarray for Multiplexed RNA Detection With Single‐Molecule Readout

Advanced Science, EarlyView.
A carrier‐based DNA nanoarray integrates programmable nucleic acid hybridization with solid‐state nanopore readout for direct RNA detection at single‐molecule resolution. A ternary encoding system enables 27 carriers with 81 addressable sensing sites, allowing the simultaneous identification of targets spanning a wide size range, from short microRNAs ...
Yunxuan Li, Yesheng Wang, Chunmiao Yu, Siyu Hou, Elli Mylona, Plamena Naydenova, Jingyuan Zhao, Hong Yuan, Jingsong Duan, Hendrik F. P. Runge, Stephen Baker, Jinbo Zhu, Ulrich F. Keyser   +12 more
wiley   +1 more source

Cultural adaptation and validation of the Arabic version of the Fear of Cancer Scale. [PDF]

Int J Nurs Stud Adv
Abusaris R, Alsaqabi D, Ibrahim AFA, A'aqoulah A, Alanazi M, Alsheikh M, Albawardi F, Awawdeh M, Salem SS.   +8 more
europepmc   +1 more source

Dual‐Network Protein Hydrogels Promote Rapid Hemostasis and Immune‐Regulated Scarless Tissue Regeneration

Advanced Science, EarlyView.
A dual‐network protein hydrogel substantially improves hemostasis and scar‐free healing.The adaptive network maintains intimate tissue contact while providing strong wet adhesion, tunable mechanics, and controlled degradation. Concurrent ROS scavenging and M2 polarization suppress fibrotic pathways, preventing scar formation.
Xiaomei Li, Guorui Zhang, Xinyue Wang, Zhongyu Liu, Ling Yang, Yuhan Bao, Min Wei, Yonglin Chen, Yanfei Ma, Wenbo Sheng, Bo Yu, Bin Li   +11 more
wiley   +1 more source

An inactivated bivalent vaccine effectively protects Carassius auratus against Aeromonas caviae and Aeromonas veronii. [PDF]

Sci Rep
Gao D, Tao L, Lu H, Suo T, Xiong J, Shan X, Zhang D, Dong H, Li R.   +8 more
europepmc   +1 more source

Controlling Photochromism of Donor‐Acceptor Stenhouse Adducts on Micro‐Dot Arrays Beyond Human‐Eyes Resolution for Dynamic Light Encryption

Advanced Science, EarlyView.
This study presents a micro‐dot array strategy for dynamic light encryption, utilizing DASA‐based photochromism with resolution beyond human‐eye capacity. By precisely controlling isomerization kinetics, the method reveals multi‐layered encrypted information under specific light irradiation, enhancing information security and anti‐counterfeiting ...
Hongtao Hu, Fanxi Sun, Hanjun Zhang, Xiao Wang, Gaolu Zhu, Jiayu Li, Mengyao Yang, Xu Deng, Yonghao Zheng, Chen Wei, Dongsheng Wang   +10 more
wiley   +1 more source

Dual Physiological Barriers Bypassed by a Silk‐Based Supramolecular Protein Delivery Platform for Neuroinflammation Mitigation in Alzheimer's Disease

Advanced Science, EarlyView.
A supramolecular nanocomplex based on phenolic‐modified silk sericin is developed to deliver antioxidant enzymes across the blood–brain barrier and escape lysosomal degradation. This dual‐barrier‐crossing system reduces neuroinflammation and improves cognitive performance in Alzheimer's disease mouse model, offering a promising strategy for protein ...
Doudou Hu, Tiandong Li, Jian He, Yujian Jiang, Yeyuan Wang, Jingchen Sun   +5 more
wiley   +1 more source

Engineering Oncolytic Virus‐Armed Macrophages for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
ZIFOA‐M is engineered by conjugating oncolytic adenovirus‐loaded ZIF‐8 nanoparticles onto macrophage surfaces via bioorthogonal chemistry. Upon tumor infiltration, the platform releases OA to downregulate CD47/CD24 on tumor cells, restoring macrophage phagocytosis.
Jilong Wang, Ning Lu, Zhuo Yan, Luyi Ye, Luyao Bai, Shanshan Yuan, Yuting Zhu, Yiru Xiong, Yongheng Bai, Yaping Chen, Junjie Deng   +10 more
wiley   +1 more source

Application of Gas Chromatographic Retention Indices to GC and GC-MS Identification with Variable Limits for Deviations Between Their Experimental and Reference Values. [PDF]

Molecules
Zenkevich IG.
europepmc   +1 more source