Results 101 to 110 of about 1,580,663 (249)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Predictive Likelihood

The Annals of Statistics, 1979
The likelihood function is the common basis of all parametric inference. However, with the exception of an ad hoc definition by Fisher, there has been no such unifying basis for prediction of future events, given past observations. This article proposes a definition of predictive likelihood which can help to remove some nonuniqueness problems in ...
openaire   +2 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Drivers of sub‐seasonal extreme rainfall and their representation in ECMWF forecasts during the Eastern African March‐to‐May seasons of 2018–2020

Meteorological Applications
In recent years, Eastern Africa has been severely impacted by extreme climate events such as droughts and flooding. In a region where people's livelihoods are heavily dependent on climate conditions, extreme hydrometeorological events can exacerbate ...
Masilin Gudoshava, Patricia Nyinguro, Joshua Talib, Caroline Wainwright, Anthony Mwanthi, Linda Hirons, Felipe deAndrade, Joseph Mutemi, Wilson Gitau, Elisabeth Thompson, Jemimah Gacheru, John Marsham, Hussen Seid Endris, Steven Woolnough, Zewdu Segele, Zachary Atheru, Guleid Artan   +16 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

China’s Well-Facilitated Farmland distribution dataset

Scientific Data
China has less than 10% of the world’s arable land but must feed more than 20% of the global population. Both climate change and farmland degradation pose significant challenges to China’s food security. In 2009, Chinese government launched a nationwide,
Abdusalam Turup, Jun Zhang, Wenchao Ma, Bingxin Ma, Yue Zhang, Zaeem Hassan Akhter, Longhui Li   +6 more
doaj   +1 more source

Predictive Medicine

, 2015
In the last part of the twentieth century, predictive medicine has gained currency as an important ideal in biomedical research and health care. Research in the genetic and molecular basis of disease suggested that the insights gained might be used to develop tests that predict the future health state of asymptomatic individuals.
openaire   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

MarineFlux ICOADS Air‐Sea Fluxes: 1990–2020

Geoscience Data Journal
Bulk turbulent heat and momentum fluxes are derived from individual marine reports from ships and moored buoys. The source dataset is the International Comprehensive Ocean–Atmosphere Data Set (ICOADS), specifically release 3.1.0 (1990–2014) and release 3.
S. R. Smith, A. Lovett, M. A. Bourassa, M. Castells   +3 more
doaj   +1 more source