Results 111 to 120 of about 6,504,273 (325)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

A review of the seismotectonics of the Makran Subduction Zone as a baseline for Tsunami Hazard Assessments

open access: yesGeoscience Letters, 2019
The Makran Accretionary Wedge (900 km across) is a consequence of northward subduction of the oceanic part of the Arabian Plate beneath the Lut and Afghan blocks in the northwestern Indian Ocean.
Mohammad Mokhtari   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Impact of Cloud Microphysics Initialization Using Satellite and Radar Data on CMA-MESO Forecasts

open access: yesRemote Sensing
High-resolution numerical weather prediction requires accurate cloud microphysical initial conditions to enhance forecasting capabilities for high-impact severe weather events such as convective storms.
Lijuan Zhu   +3 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Porphyra Polysaccharides Alleviated High-Carbohydrate Diet-Induced Growth Retardation, Lipid Deposition, Impairment of Immune and Antioxidant Functions, and Intestinal Morphology in Rabbitfish (Siganus canaliculatus)

open access: yesAquaculture Nutrition
Porphyra polysaccharide (PPS), derived from marine red seaweeds of the Porphyra genus, has been reported to improve growth performance, lipid metabolism, and antioxidant capability in animals.
Ruixin Li   +11 more
doaj   +1 more source

Review of Pre-processing Techniques for Meteorological Satellite Data Assimilation in Numerical Prediction

open access: yes应用气象学报
Satellite data assimilation pre-processing plays a crucial role in bridging satellite data pre-processing and numerical weather prediction model assimilation.
Ma Gang   +7 more
doaj   +1 more source

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