Results 101 to 110 of about 879,596 (317)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Submarket, Heterogeneity and Hedonic Prediction Accuracy of Real Estate Prices: Evidence from Shanghai [PDF]

This paper contributes to the literature by examining how much the prediction accuracy of real estate prices could be improved by applying hedonic equations at suitably defined disaggregate levels and incorporating directional heterogeneity of distance ...
Jie Chen, Qianjin Hao
core  

Predicting Diagnostic Accuracy [PDF]

Journal of General Internal Medicine, 2007
To the Editor: The report by Nendaz et al.1 on diagnostic accuracy highlighted the importance of previous exposure to similar cases and generating hypotheses early in the encounter. However, I was surprised the authors did not reference the descriptive article by Kassirer and Gorry2 in which similar conclusions were reached.
openaire   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Evaluation and Design Exploration of Solar Harvested-Energy Prediction Algorithm [PDF]

To respond to variations in solar energy, harvested-energy prediction is essential to harvested-energy management approaches. The effectiveness of such approaches is dependent on both the achievable accuracy and computation overhead of prediction ...
Ali, Mustafa, Atienza, David, Al-Hashimi, Bashir, Recas, Joaquin   +3 more
core  

Best Linear Unbiased Prediction of Genomic Breeding Values Using a Trait-Specific Marker-Derived Relationship Matrix [PDF]

, 2010
Background: With the availability of high density whole-genome single nucleotide polymorphism chips, genomic selection has become a promising method to estimate genetic merit with potentially high accuracy for animal, plant and aquaculture species of ...
Bijma, Piter, Bijma Piter, Dirk-Jan de Koning, Liu, J.F., Bijma, P., de Koning Dirk-Jan, Zhang, Zhe, Ding, Xiangdong, Zhang, Qin, Koning, D.J., de, Liu, Jianfeng, Qin Zhang, de Koning, Dirk-Jan, Zhang Qin, Zhe Zhang, Z., Ding, Z., Zhang Zhe, Ding Xiangdong, Piter Bijma, Jianfeng Liu, Xiangdong Ding, Zhe Zhang, Liu Jianfeng, de Koning, D.J.   +23 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Prediction of haplotypes for ungenotyped animals and its effect on marker-assisted breeding value estimation [PDF]

, 2010
Background: In livestock populations, missing genotypes on a large proportion of animals are a major problem to implement the estimation of marker-assisted breeding values using haplotypes.
Calus, M.P.L., Han A Mulder, Roel F Veerkamp, Veerkamp, R.F., Mulder, H.A., Mario PL Calus   +5 more
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source