Results 51 to 60 of about 872,279 (317)
Improving the accuracy of protein secondary structure prediction using structural alignment
, 2006 Background: The accuracy of protein secondary structure prediction has steadily improved over the past 30 years. Now many secondary structure prediction methods routinely achieve an accuracy (Q3) of about 75%.
Wishart, D.S. +3 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Estimating the Predictive Accuracy of a Classifier [PDF]
, 2001 This paper investigates the use of meta-learning to estimate the predictive accuracy of a classifier. We present a scenario where meta-learning is seen as a regression task and consider its potential in connection with three strategies of dataset characterization.
Hilan Bensusan, Alexandros Kalousis
openaire +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Enhancing genomic prediction with Stacking Ensemble Learning in Arabica Coffee
Frontiers in Plant ScienceCoffee Breeding programs have traditionally relied on observing plant characteristics over years, a slow and costly process. Genomic selection (GS) offers a DNA-based alternative for faster selection of superior cultivars. Stacking Ensemble Learning (SEL)
Moyses Nascimento +7 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
An Intelligent Lightning Warning System Based on Electromagnetic Field and Neural Network
Energies, 2019 Prediction of lightning occurrence has significant relevance for reducing potential damage to electric installations, buildings, and humans. However, the existing lightning warning system (LWS) operates using the threshold method and has low prediction ...
Guoming Wang +4 more
doaj +1 more source
Why and How to Switch to Genomic Selection: Lessons From Plant and Animal Breeding Experience
Frontiers in Genetics, 2021 The present study is a transversal analysis of the interest in genomic selection for plant and animal species. It focuses on the arguments that may convince breeders to switch to genomic selection.
R2D2 Consortium +4 more
doaj +1 more source
, 2023 Sam Multack,1 Nellie Plummer,1 Gerard Smits,2 Brad Hall3 1Multack Eye Care, Frankfort, IL, USA; 2CSC, Inc., Santa Barbara, CA, USA; 3Sengi, Penniac, NB, CanadaCorrespondence: Sam Multack, Multack Eye Care, 22200 Wolf Road, Frankfort, IL, 60423, USA, Tel +
Smits G, Multack S, Hall B, Plummer N
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source