Results 61 to 70 of about 4,208,808 (305)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Accuracy of circulating adiponectin for predicting gestational diabetes : a systematic review and meta-analysis [PDF]

, 2016
Aims/hypothesis Universal screening for gestational diabetes mellitus (GDM) has not been implemented, and this has had substantial clinical implications. Biomarker-directed targeted screening might be feasible.
Kelsey, Tom, Stamatina Iliodromiti, Nelson, Scott M., Iliodromiti, S, Sattar, N, Thomas W. Kelsey, Sattar, Naveed, Kelsey, TW, Robert S. Lindsay, Sassarini, J, Scott M. Nelson, Jennifer Sassarini, Sassarini, Jennifer, Naveed Sattar, Lindsay, Robert S., Nelson, SM, Iliodromiti, Stamatina, Kelsey, Thomas W., Lindsay, R, Nelson, S, Lindsay, RS   +20 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Enhancing genomic prediction with Stacking Ensemble Learning in Arabica Coffee

Frontiers in Plant Science
Coffee Breeding programs have traditionally relied on observing plant characteristics over years, a slow and costly process. Genomic selection (GS) offers a DNA-based alternative for faster selection of superior cultivars. Stacking Ensemble Learning (SEL)
Moyses Nascimento, Moyses Nascimento, Ana Carolina Campana Nascimento, Ana Carolina Campana Nascimento, Camila Ferreira Azevedo, Antonio Carlos Baiao de Oliveira, Eveline Teixeira Caixeta, Diego Jarquin   +7 more
doaj   +1 more source

A higher prediction accuracy–based alpha–beta filter algorithm using the feedforward artificial neural network

CAAI Transactions on Intelligence Technology, 2023
The alpha–beta filter algorithm has been widely researched for various applications, for example, navigation and target tracking systems. To improve the dynamic performance of the alpha–beta filter algorithm, a new prediction learning model is proposed ...
Junaid Khan, Eunkyu Lee, Kyungsup Kim
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Artificial neural network algorithm for online glucose prediction from continuous glucose monitoring. [PDF]

, 2010
Background and Aims: Continuous glucose monitoring (CGM) devices could be useful for real-time management of diabetes therapy. In particular, CGM information could be used in real time to predict future glucose levels in order to prevent hypo ...
Pérez Gandía, Carmen, DE LEIVA A, Hernando Pérez, María Elena, Gómez Aguilera, Enrique J., SPARACINO, GIOVANNI, Rigla Cros, Mercedes, RIGLA M, GOMEZ EJ, HERNANDO ME, Leiva, Alberto de, Sparacino, G., PEREZ GANDIA C, COBELLI, CLAUDIO, Facchinetti, A., Cobelli, C., FACCHINETTI, ANDREA   +15 more
core   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Combining probabilistic neural networks and decision trees for maximally accurate and efficient accident prediction

, 2010
The extent to which accident severity can be predicted from accident-related data collected at a variety of locations is investigated. The 2005 accident dataset brought together by the Republic of Cyprus Police is employed; this dataset comprises 1407 ...
Miltiadis Chalikias, Dora Souliou, Souliou, Dora, Gregoriades, A, Tambouratzis, T, Tambouratzis, Tatiana, Gregoriades, A.,, Souliou, D, Souliou, D.,, Chalikias, M.,, Tatiana Tambouratzis, Gregoriades, A., Chalikias, M, Chalikias, M., Chalikias, Miltiadis, Tampouratzi, Tatiani, Souliou, D., Andreas Gregoriades, Gregoriades, Andreas, Tampouratzi, Tatiani,   +19 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source