Results 91 to 100 of about 23,967,054 (309)

Estimation of Final Size of COVID-19 Epidemic in Balochistan Province, Pakistan

The International Journal of Frontier Sciences
COVID-19 is a new disease that is spreading very fast in Pakistan. Cases have been reported from all of the provinces including Balochistan. The first two confirmed cases in Pakistan had travel history by road from Iran to Balochistan, hence SIR model ...
Muhammad Arif, Aftab Kakar, Ehsan Larik
doaj   +1 more source

In-depth mining of clinical data: the construction of clinical prediction model with R.

Annals of Translational Medicine, 2019
This article is the series of methodology of clinical prediction model construction (total 16 sections of this methodology series). The first section mainly introduces the concept, current application status, construction methods and processes ...
Zhi-rui Zhou, Wei-wei Wang, Yan Li, Kairui Jin, Xuan Wang, Zi-Wei Wang, Yishan Chen, Shaoqian Wang, Jing Hu, Huina Zhang, Po Huang, Guozhen Zhao, Xing-Xing Chen, Bohua Li, Tian-Song Zhang   +14 more
semanticscholar   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Neural–genetic–environmental evidence for a disease factor in mental and physical health multimorbidity

Nature Communications
Increasing evidence reveals the presence of multimorbidity across physical and mental disorders. A general disease factor (d factor) has been recently identified to capture the shared liability across these conditions, yet its biological basis remains ...
Jin Chen, Yuning Zhang, Shu Liu, Miguel Garcia-Argibay, Tianye Jia, Jujiao Kang, Wei Li, Marco Solmi, Hongyi Sun, Wenqi Liu, Congying Chu, Samuele Cortese, Jiaojian Wang   +12 more
doaj   +1 more source

A Prediction Model for Chemotherapy-Induced Thrombocytopenia Based on Real-World Data and a Close Relationship Between AST/ALT Ratio and Platelet Count in Patients with Solid Tumors [Corrigendum]

International Journal of General Medicine, 2022
Song B, Zhou S, Li C, et al. Int J Gen Med. 2022;15:8003–8015. The authors have advised the author and affiliations list on page 8003 is incorrect. The correct details are as follows.
Song B, Zhou S, Li C, Zheng H, Zhang X, Jin X, Fu J, Hu H   +7 more
doaj  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Research on soil moisture prediction model based on deep learning

PLoS ONE, 2019
Soil moisture is one of the main factors in agricultural production and hydrological cycles, and its precise prediction is important for the rational use and management of water resources.
Yu Cai, Wengang Zheng, Xin Zhang, Lili Zhangzhong, X. Xue   +4 more
semanticscholar   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source