Results 71 to 80 of about 15,951,579 (313)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Numerical Simulation of Two Hailstorm Processes Based on CMA-MESO
应用气象学报High-resolution numerical models coupled with detailed cloud microphysical schemes are essential tools for in-depth investigation of hail cloud structure and formation mechanisms.
Chen Xiaomin +4 more
doaj +1 more source
DELWAVE 1.0: deep learning surrogate model of surface wave climate in the Adriatic Basin [PDF]
Geoscientific Model DevelopmentWe propose a new point-prediction model, the DEep Learning WAVe Emulating model (DELWAVE), which successfully emulates the behaviour of a numerical surface ocean wave model (Simulating WAves Nearshore, SWAN) at a sparse set of locations, thus enabling ...
P. Mlakar +8 more
doaj +1 more source
Prediction of catastrophes: An experimental model [PDF]
Physical Review E, 2012 Catastrophes of all kinds can be roughly defined as short duration-large amplitude events following and followed by long periods of "ripening". Major earthquakes surely belong to the class of 'catastrophic' events. Because of the space-time scales involved, an experimental approach is often difficult, not to say impossible, however desirable it could ...
Peters, Randall D. +2 more
openaire +3 more sources
Effective workflow from multi-modal MRI data to model-based prediction
Predicting human behavior from neuroimaging data remains a complex challenge in neuroscience. To address this, we propose a systematic and multi-faceted framework that incorporates a model-based workflow using dynamical brain models.
Kevin J. Wischnewski +3 more
core +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Modelling: Predictive yield [PDF]
Nature, 2013 Farmers would benefit from better long-range weather forecasts. What else can science provide to help them decide what to plant?
openaire +2 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Synthesizing benchmarks for predictive modeling [PDF]
2017 IEEE/ACM International Symposium on Code Generation and Optimization (CGO), 2017 Predictive modeling using machine learning is an effective method for building compiler heuristics, but there is a shortage of benchmarks. Typical machine learning experiments outside of the compilation field train over thousands or millions of examples.
Cummins, C +3 more
openaire +6 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source