Results 91 to 100 of about 1,720,597 (315)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Crustal Structure and Magmatic System of Mount Erebus in Antarctica constrained by Receiver Functions and Seismic Velocity Analysis

Scientific Reports
Mount Erebus, the world’s southernmost active volcano in Antarctica, offers a unique opportunity to investigate crustal controls on persistent magmatism within a caldera environment.
Pousali Mukherjee, Yoshihiro Ito, Kajaljyoti Borah, Emmanuel S. Garcia, Dipok K. Bora   +4 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Collective suffix tree-based models for location prediction [PDF]

, 2013
Models developed for the prediction of location, where a specific individual will be present at a future time, are typically implemented using a one-model-per-user approach which cannot be employed for inferring collective or social behaviours involving ...
Eldaw, Muawya Habib Sarnoub, Mark Levene, Levene, Mark, Roussos, George, Muawya Habib Sarnoub Eldaw, George Roussos   +5 more
core   +1 more source

Multi‐Scale Decomposition for Skillful All‐Season MJO Prediction With Deep Learning

Geophysical Research Letters
The Madden‐Julian Oscillation (MJO) is a key intraseasonal atmospheric pattern in the tropics, significantly influencing global weather and extreme events.
Miae Kim, Daehyun Kang, Soo‐Jin Sohn, Gayoung Kim, Jinyoung Rhee, Sunyong Kim   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Simulation-Assignment-Based Travel Time Prediction Model for Traffic Corridors

, 2014
Travel time prediction in Advanced Traveler Information Systems is an important issue, because travel time is a major factor in motorists' decisions to avoid congestion and incidents. A simulation-assignment-based travel time prediction model for traffic
Hu, Ta-Yin; Tong, Chee-Chung; Liao, Tsai-Yun; Ho, Wei-Ming
core   +1 more source

Recent Enhancements to the Genetic Risk Prediction Model BRCAPRO

Cancer Informatics, 2015
BRCAPRO is a widely used model for genetic risk prediction of breast cancer. It is a function within the R package BayesMendel and is used to calculate the probabilities of being a carrier of a deleterious mutation in one or both of the BRCA genes, as ...
Emanuele Mazzola, Amanda Blackford, Giovanni Parmigiani, Swati Biswas   +3 more
doaj   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source