Results 221 to 230 of about 4,112,292 (287)

Construction and Evaluation of a Prediction Model for Neonatal Hyperbilirubinemia. [PDF]

Int J Gen Med
Xu S, Guo X, Li C, Chen J, Zhang C.
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Development of a risk prediction model for left ventricular thrombosis in STEMI patients. [PDF]

Front Cardiovasc Med
Wang J, Ma P, Xu Q, Hai L, Zhang S.
europepmc   +1 more source

Proteomic Prediction Models

Clinical Chemistry
openaire   +2 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Establishment of prediction model for breast lesion using automated breast ultrasound system. [PDF]

Quant Imaging Med Surg
Wang X, Wang X, Wang X, He Y, Li J, Wang T, Fan Z, Huo L, Ouyang T.   +8 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Development and validation of a prediction model for primary non-response to IL-17A inhibitors in psoriasis. [PDF]

Front Med (Lausanne)
Yu Q, Jiang Y, Hu Y, Dai M, Li S, Cai J, Yang N, Zhang Y, Huang Y, Guo C, Shi Y, Lu J.   +11 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Mamba6mA: a Mamba-based DNA N6-methyladenine site prediction model. [PDF]

Bioinformatics
Zhao Q, Zhang Z, Chen T, Mao Q, Shi H, Chen J, Zhao Z, Fan X.   +7 more
europepmc   +1 more source