The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
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Risk factors and nomogram prediction model for hypocalcemia in patients undergoing hemodialysis. [PDF]
Chen S +4 more
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The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
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A nomogram prediction model for plastic bronchitis in children with refractory <i>Mycoplasma pneumoniae</i> pneumonia. [PDF]
He H +7 more
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Directed evolution of enzymes at the crossroads of tradition and innovation
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
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Construction of a risk prediction model for severe community-acquired pneumonia in children in Qinghai region. [PDF]
Ning X, Cao H, Hao E, Cai X, Li Y, Li L.
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This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha +4 more
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Development and Validation of a Postoperative Delirium Prediction Model for Patients Undergoing Gastrointestinal Surgery. [PDF]
Huang Z +5 more
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LiBRe: A Ligand-Aware Sequence-Based Binding Residue Prediction Model for Virtual Screening. [PDF]
Kang K, Kim M, Kim J, Sel S, Song G.
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Erratum: Establishment and Validation of a Nomogram Clinical Prediction Model for Nosocomial Candidemia: An 18-Year Retrospective Analysis [Corrigendum]. [PDF]
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