Results 231 to 240 of about 29,110,946 (332)

Infectious disease prediction model based on optimized deep learning algorithm. [PDF]

Front Public Health
Cao Q, Zheng J, Liu Y, Li Z, Xu J, Zhao H, Feng L, Jin Y.   +7 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Validation of a Clinical and Polygenic Risk Prediction Model for Ovarian Cancer in the Nurses' Health Study. [PDF]

Cancer Prev Res (Phila)
Patel K, Dite GS, Spaeth EL, Rosner BA.
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Frailty Prediction Model for Elderly Diabetic Peripheral Neuropathy Patients. [PDF]

Diabetes Metab Syndr Obes
Xie X, Huang Y, Wang Y, Chen W, Liang X, Xiong C, Zou X.   +6 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Recent Enhancements to the Genetic Risk Prediction Model BRCAPRO

Cancer Informatics, 2015
Emanuele Mazzola, Amanda Blackford, Giovanni Parmigiani, Swati Biswas   +3 more
doaj  

Hypoxemia prediction model based on XGBoost during sedation for gastrointestinal endoscopy. [PDF]

Front Med (Lausanne)
Zhao R, Chen Z, Teng Q, Xu T, Li Q, Gong H, Ji H, Zhang H.   +7 more
europepmc   +1 more source