Results 81 to 90 of about 29,110,946 (332)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

A Review of Bankruptcy Prediction Studies: 1930-Present [PDF]

, 2007
One of the most well-known bankruptcy prediction models was developed by Altman [1968] using multivariate discriminant analysis. Since Altman\u27s model, a multitude of bankruptcy prediction models have flooded the literature.
Akers, Michael D., Giacomino, Don, Gissel, Jodi L.   +2 more
core   +1 more source

Radiomics-Based Outcome Prediction for Pancreatic Cancer Following Stereotactic Body Radiotherapy [PDF]

, 2020
(1) Background: Radiomics use high-throughput mining of medical imaging data to extract unique information and predict tumor behavior. Currently available clinical prediction models poorly predict treatment outcomes in pancreatic adenocarcinoma ...
Baine, Michael, Bavitz, Kyle, Du, Qian, Hollingsworth, Michael, Kamal, Ahsan, Liang, Xiaoying, Lin, Chi, McAlister, Josiah, Parr, Elsa, Rux, Gerard, Zhang, Chi, Zheng, Dandan   +11 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Improvements of the shock arrival times at the Earth model STOA

, 2015
Prediction of the shocks' arrival times (SATs) at the Earth is very important for space weather forecast. There is a well-known SAT model, STOA, which is widely used in the space weather forecast.
Liu, H. -L., Qin, G.
core   +1 more source

A Unified Online Deep Learning Prediction Model for Small Signal and Transient Stability

IEEE Transactions on Power Systems, 2020
This paper proposes a novel unified prediction approach for both small-signal and transient rotor angle stability as opposed to other studies that have only addressed transient rotor angle stability. Deep learning techniques are employed in this paper to
Syafiq Kamarul Azman, Younes J. Isbeih, M. E. Moursi, Khaled M. Elbassioni   +3 more
semanticscholar   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Methodological standards for the development and evaluation of clinical prediction rules: a review of the literature

Diagnostic and Prognostic Research, 2019
Clinical prediction rules (CPRs) that predict the absolute risk of a clinical condition or future outcome for individual patients are abundant in the medical literature; however, systematic reviews have demonstrated shortcomings in the methodological ...
Laura E. Cowley, Daniel M. Farewell, Sabine Maguire, Alison M. Kemp   +3 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Multi‐Scale Decomposition for Skillful All‐Season MJO Prediction With Deep Learning

Geophysical Research Letters
The Madden‐Julian Oscillation (MJO) is a key intraseasonal atmospheric pattern in the tropics, significantly influencing global weather and extreme events.
Miae Kim, Daehyun Kang, Soo‐Jin Sohn, Gayoung Kim, Jinyoung Rhee, Sunyong Kim   +5 more
doaj   +1 more source