Results 241 to 250 of about 2,497,925 (305)

Translating Mortality Hazard Ratios into Remaining-Lifespan Measures in Older Adults Using Japanese Complete Life Tables: A Deterministic Reference-Table Study. [PDF]

Geriatrics (Basel)
Shibuya T, Kutsuna N, Ohida T, Nakamura M, Kinugasa H.   +4 more
europepmc   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Robust inference and correlates from genetic associations with personality. [PDF]

Nature
Schwaba T, Clapp Sullivan ML, Akingbuwa WA, Ilves K, Tanksley PT, Williams CM, Dragostinov Y, Mallard TT, Tubbs JD, Liao W, Ackerman LS, Fealy JCM, Hemani G, de la Fuente J, Smith GD, Gupta P, Stein MB, Gelernter J, Levey DF, Võsa U, Ausmees L, Realo A, Estonian Biobank Research Team, Vaht M, Allik J, Esko T, Mõttus R, Vainik U, Jonsdottir GA, Thorleifsson G, Gunnarsson ÁF, Bjornsdottir G, Thorgeirsson TE, Stefansson H, Stefansson K, Cheesman R, Qin Q, Corfield EC, Ask H, Torvik FA, Ystrom E, Tesli M, Boomsma DI, de Geus EJC, Hottenga JJ, Melo DC, Snieder H, Hartman CA, Xia C, Campbell A, Luciano M, Deary IJ, Hill WD, Jang SK, Vrieze SI, Abecasis G, Lupton MK, Mitchell BL, Viher PV, Colodro-Conde L, Martin NG, Medland SE, Derks EM, Wormington B, Kaprio J, Silventoinen K, Palviainen T, Musial A, Rimfeld K, Plomin R, Malanchini M, Dick DM, Aliev F, COGA Collaborators, Spit for Science Working Group, Wesseldijk LW, Ullén F, Mosing MA, Kranzler HR, Nunez Y, Beck S, Polimanti R, Edwards T, Giannelis A, Willoughby EA, Lee JJ, McGue M, Terracciano A, Marongiu M, Fiorillo E, Cucca F, Sutin AR, van der Most PJ, Oldehinkel AJ, Kretschmer T, Shabalin AA, Docherty AR, Krueger RF, Freilich CD, Mishra BH, Lehtimäki T, Raitakari OT, Kähönen M, Saarinen A, Dobewall H, Keltikangas-Järvinen L, Berger K, Herrera-Rivero M, Streit F, Awasthi S, Witt SH, Tuhkanen J, Räikkönen K, Eriksson JG, Lahti J, Davies G, Redmond P, Taylor A, Corley J, Russ TC, Ciullo M, Nutile T, Ding J, Qian Y, Tanaka T, Ferrucci L, Zillich L, Sirignano L, Harden KP, Genç E, Gajewski PD, Getzmann S, Fraenz C, Schneider Peñate JE, Lis S, Hall ASM, Schmahl C, Herpertz SC, Abdellaoui A, Nivard MG, Tucker-Drob EM.   +140 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Severe Infection Outcomes With SGLT2 Versus DPP-4 Inhibitors in Type 2 Diabetes: A Systematic Review and Active-Comparator Meta-Analysis of Real-World Cohorts. [PDF]

Endocrinol Diabetes Metab
Huang YM, Wang JH, Huang WT, Hsu JZ, Teh SH.   +4 more
europepmc   +1 more source

A public-data audit of transcriptomic prognostic transportability in R-CHOP-treated diffuse large B-cell lymphoma. [PDF]

PLoS One
Li Y, Xiong G, Feng W, Chen Q, Qin Y, Hong H, Lin L.   +6 more
europepmc   +1 more source

Study-Aware Meta-Analysis Reveals a Recurrent Proteostasis Program and Context-Dependent Gene-Level Responses in Bovine Heat-Stress Transcriptomes. [PDF]

Genes (Basel)
Zhao X, Chang H, Zhang Q, Zhao Z, He S, Lu Z, Xiang X.   +6 more
europepmc   +1 more source

SELFormerMM: multimodal molecular representation learning via SELFIES, structure, text, and knowledge graph integration. [PDF]

Bioinformatics
Ulusoy E, Bostancı Ş, Deniz BE, Doğan T.   +3 more
europepmc   +1 more source

Systematic review and meta-analysis of AI in lung cancer metastasis imaging for diagnosis and prognosis. [PDF]

NPJ Digit Med
Sun Y, Jin L, Wang B, Yang C, Fan Y, Zhao P, Zhang Y, Ge X, Sha X, Su J, Jiang X.   +10 more
europepmc   +1 more source