Results 91 to 100 of about 472,321 (294)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Predictive Control for Alleviation of Gust Loads on Very Flexible Aircraft
, 2014 In this work the dynamics of very flexible aircraft are described by a set of non-linear, multi-disciplinary equations of motion. Primary structural components are represented by a geometrically-exact composite beam model which captures the large dynamic
Chen P. +8 more
core +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
ARTMAP-IC and Medical Diagnosis: Instance Counting and Inconsistent Cases [PDF]
, 1996 For complex database prediction problems such as medical diagnosis, the ARTMAP-IC neural network adds distributed prediction and category instance counting to the basic fuzzy ARTMAP system.
Carpenter, Gail A., Markuzon, Natalya
core +1 more source
Observation and prediction for the heat equation
Journal of Mathematical Analysis and Applications, 1969 Mathematics Technical ...
Mizel, V.J, Seidman, T.I
openaire +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Choosing and using lung function prediction equations [PDF]
European Respiratory Journal, 2016 In a survey of lung function laboratories some years ago, a surprisingly large number of laboratories were found not to know exactly which equations were being used to help them make judgements about their patients' results [1]. Many manufacturers' equipment includes a choice of reference values and the default selection may end up being used without ...
openaire +2 more sources
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
PLoS ONE, 2013 BackgroundThere have been few published studies on spirometric reference values for healthy children in China. We hypothesize that there would have been changes in lung function that would not have been precisely predicted by the existing spirometric ...
Ya-Nan Ma +10 more
doaj +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source