Results 81 to 90 of about 1,308,678 (317)

Immunoinformatics and structural aided approach to develop multi-epitope based subunit vaccine against Mycobacterium tuberculosis

Scientific Reports
Tuberculosis is a highly contagious disease caused by Mycobacterium tuberculosis (Mtb), which is one of the prominent reasons for the death of millions worldwide.
Guneswar Sethi, Rinku Polachirakkal Varghese, Avinash Kant Lakra, Subhashree Subhasmita Nayak, Ramadas Krishna, Jeong Ho Hwang   +5 more
doaj   +1 more source

Time Delay Compensation and Stability Analysis of Networked Predictive Control Systems Based on Hammerstein Model [PDF]

, 2007
A novel approach is proposed for a networked control system with random delays containing a nonlinear process based on a Hammerstein model. The method uses a time delay two step generalized predictive control (TDTSGPC), which consists of two parts, one ...
G.P. Liu, Zhao, Y.-B., Y.B. Zhao, Rees, D., D. Rees, Liu, G.P.   +5 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Predictive Model Selection

Journal of the Royal Statistical Society Series B: Statistical Methodology, 1995
SUMMARY We consider the problem of selecting one model from a large class of plausible models. A predictive Bayesian viewpoint is advocated to avoid the specification of prior probabilities for the candidate models and the detailed interpretation of the parameters in each model.
Laud, Purushottam W., Ibrahim, Joseph G.
openaire   +2 more sources

A Formulation of nonlinear model predictive control using automatic differentiation [PDF]

, 2005
An efficient algorithm is developed to alleviate the computational burden associated with nonlinear model predictive control (NMPC). The new algorithm extends an existing algorithm for solutions of dynamic sensitivity from autonomous to non-autonomous ...
Cao, Yi
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A nonparametric predictive alternative to the Imprecise Dirichlet Model: the case of a known number of categories [PDF]

, 2006
Nonparametric Predictive Inference (NPI) is a general methodology to learn from data in the absence of prior knowledge and without adding unjustified assumptions.
Augustin, Thomas, T. Augustin, F. P. A. Coolen, Coolen, F. P. A.   +3 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

New horizons of microphysiological systems: India forging its path in human-relevant research

Biology Open, 2023
Surat Parvatam, Kasturi Mahadik, Anushka Banerjee, Kadambari Patil, V. Radha, Madhusudhana Rao   +5 more
doaj   +1 more source