Results 261 to 270 of about 127,481 (314)

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

F-DATA: A Fugaku Workload Dataset for Job-centric Predictive Modelling in HPC Systems. [PDF]

Sci Data
Antici F, Bartolini A, Domke J, Kiziltan Z, Yamamoto K.   +4 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Predictive modelling of air pollution affecting human tuberculosis risk on Mainland China. [PDF]

Sci Rep
Qin B, He R, Qin X, Jiang J, Zhou C, Wu S, Zhu J, Wu S, Chen J, Xue J, He K, Liu C, Ma J, Zhan X.   +13 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Identifying dynamic reproducible brain states using a predictive modelling approach. [PDF]

Imaging Neurosci (Camb)
O'Connor D, Horien C, Mandino F, Constable RT.   +3 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Predictive modelling of Uranium (²³⁸U) and Thorium (²³²Th) in soils of Central India: integrating ICP-MS/MS, spectroscopic, and machine learning models. [PDF]

Sci Rep
Tagore GS, Sahu DK, Sharma YM, Srivastava S, Nema RK.   +4 more
europepmc   +1 more source

Characterization and predictive modelling of quasi-saturated hydraulic conductivity across land use systems in the Northwest Himalayas. [PDF]

Sci Rep
Singh D, Singh N, Singh H, Islam S, Dwivedi AK, Ojha CSP, Barh A.   +6 more
europepmc   +1 more source