Results 181 to 190 of about 622,973 (267)

Can Deltoid Hounsfield Unit/Supraspinatus Hounsfield Unit Predict Postoperative Rotator Cuff Retear? [PDF]

Orthop Surg
Wang X, Liu G, Wang X, Ma Y, Zhou H, Shen G.   +5 more
europepmc   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Negative Predictive Value of Allergologic Work-Up with Iodinated Contrast Media in 'Real-Life' Practice. [PDF]

J Clin Med
Specjalski K, Iwaszko I, Typiak D, Juszkiewicz D, Szablewska W, Skotnicki M, Le N, Powietrzyński M, Strukowski A, Śledzik J, Chełmińska M, Niedoszytko M.   +11 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Multi-modal AI: Integrating electrocardiography with molecular biomarkers for noninvasive detection of cardiac allograft rejection. [PDF]

JHLT Open
Chen K, Koesmahargyo V, Ronan R, Barbhaiya CR, Bernstein SA, Kushnir A, Garber L, Yang F, Aizer A, Reyentovich A, Chinitz LA, Goldberg RI, Jankelson L.   +12 more
europepmc   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Diagnostic Value of the Anal Endoluminal Functional Luminal Imaging Probe for the Diagnosis of Anismus: An Exploratory Study. [PDF]

Neurogastroenterol Motil
Desprez C, Duflot T, Melchior C, Gourcerol G, Zifan A, Houivet E, Savoye-Collet C, Leroi AM.   +7 more
europepmc   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Harnessing AI for Hypothyroidism Monitoring Using Wearable-Derived Heart Rate Data: Retrospective Cohort Study. [PDF]

JMIR AI
Shin K, Jung Y, Yoo WS, Kim MJ, Oh TJ, Moon JH, Kong SH, Lee WW, Moon JH.   +8 more
europepmc   +1 more source