Results 211 to 220 of about 1,539,986 (394)

Peak systolic blood pressure during preparticipation exercise testing in 12,083 athletes: age, sex, and workload-indexed values and predictors

P Pesova, Bogna Jiravska Godula, Otakar Jiravský, Libor Jelínek, Markéta Sovová, Katarína Moravcová, Jaromír Ožana, Ivan Ranič, Radek Neuwirth, Roman Miklík, Matěj Pekár, Libor Škňouřil, Vladimír Tuka, Eliška Sovová   +13 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Predictive Value of Phosphorylated Insulin-like Growth Factor Binding Protein-1( Pigfbp-1 ) ( Bedside Test ) in Preterm Labor

, 2014
Amro Elsayed El-Ezz, Alsaeed Elsayed A. Abo Askar   +1 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Constructing a precise prediction model for screening growth hormone deficiency in children in a single laboratory setting: using the serum IGF-1-to-age ratio as a promising predictive marker. [PDF]

Transl Pediatr
Qiu S, Zhao T, Lian Y, Liu C.
europepmc   +1 more source

Positive Predictive Value of Diagnostic Test [PDF]

, 2020
openaire   +1 more source

Predictive Value of Combined Urinary Sodium, Urinary Fek, and Urinary Uk/Ucr Tests in Sepsis-Induced Early Acute Kidney Injury [PDF]

Yu Wang, Chao Ruan, Xiaodan Miao, Bing Li, Wenlu Ma   +4 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Normal pressure hydrocephalus and the predictive value of presurgical tests

Arquivos de Neuro-Psiquiatria
Benito P. Damasceno
doaj   +1 more source

Risk Factors and Predictive Value of Interleukin-6 and Lymphocyte Count in Sepsis-Induced Coagulopathy: A Retrospective Study. [PDF]

Clin Appl Thromb Hemost
B S, Yang L.
europepmc   +1 more source