Results 221 to 230 of about 1,276,953 (303)

Hybrid feature-selection and diversity-guided stacking framework for interpretable ensemble learning: Application to COVID-19 mortality prediction. [PDF]

PLoS One
Mohtasham F, Hashemi Nazari SS, Pourhoseingholi MA, Kavousi K, Zali MR.   +4 more
europepmc   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

PLR/SII/D-dimer iron triangle: a novel precision prediction strategy for <i>Mycoplasma pneumoniae</i> pneumonia-associated plastic bronchitis in children. [PDF]

Front Med (Lausanne)
Feng M, Li W, Ai T, Fan Y, Zhang L, Xia W, Xie C.   +6 more
europepmc   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Cognitive function is associated with risk of conversion to secondary progressive multiple sclerosis: A cross-sectional study. [PDF]

PLoS One
Mirmosayyeb O, Mohammadi I, Rajai Firouzabadi S, Vaheb S, Yazdan Panah M, Fuchs TA, Weinstock-Guttman B, Shaygannejad V.   +7 more
europepmc   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Plasma neurofilament light chain and glial fibrillary acidic protein in the differential diagnosis of acute vertigo in the emergency department. [PDF]

J Neurol
Haidegger M, Berger N, Fandler-Höfler S, Gattermeyer-Kell L, Hatab I, Kneihsl M, Monsberger S, Niedrist T, Tafrali C, Martinez-Serrat M, Benkert P, Kuhle J, Enzinger C, Khalil M, Gattringer T.   +14 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Implementation of ML Flow for leprosy contacts in Brazil: Opportunities, pitfalls, and safeguards. [PDF]

PLoS Negl Trop Dis
Talhari C, Farias CDP, Miot HA, Talhari S.   +3 more
europepmc   +1 more source