Results 51 to 60 of about 3,092,370 (305)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

A parallel in time/spectral collocation combined with finite difference method for the time fractional differential equations

Journal of Algorithms & Computational Technology, 2021
In this article, we consider the numerical solution for the time fractional differential equations (TFDEs). We propose a parallel in time method, combined with a spectral collocation scheme and the finite difference scheme for the TFDEs.
Xianjuan Li, Yanhui Su
doaj   +1 more source

Apex Method: A New Scalable Iterative Method for Linear Programming

Mathematics, 2023
The article presents a new scalable iterative method for linear programming called the “apex method”. The key feature of this method is constructing a path close to optimal on the surface of the feasible region from a certain starting point to the exact ...
Leonid B. Sokolinsky, Irina M. Sokolinskaya   +1 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Simulating the Brio model via generalized Rusanov scheme in magnetohydrodynamics

Results in Physics
The Brio system is a nonlinear system of conservation laws that is used to analyze plasmas. The current research presents numerical solutions to this model exposed to initial conditions using the generalized Rusanov (G. Rusanov) scheme.
H.G. Abdelwahed, Mahmoud A.E. Abdelrahman, Turki saad bin hussain, A.F. Alsarhan, Kamel Mohamed   +4 more
doaj   +1 more source

A new method for controlling an induction motor using a hybrid discretization model predictive field orientated control.

PLoS ONE, 2022
The dynamic performance of the Model Predictive Control (MPC) of an Induction Motor (IM) relies on the accuracy and computational efficiency of the Discretisation Technique (DT).
Hasan Alqaraghuli, Abdul Rashid Husain, Nik Rumzi Bin Nik Idris, Waqas Anjum, Muhammad Abbas Abbasi   +4 more
doaj   +1 more source

A spent nuclear fuel source term calculation code BESNA with a new modified predictor-corrector scheme

Nuclear Engineering and Technology, 2022
This paper introduces a new point depletion-based source term calculation code named BESNA (Bateman Equation Solver for Nuclear Applications), which is aimed to estimate nuclide inventories and source terms from spent nuclear fuels.
Duy Long Ta, Ser Gi Hong, Dae Sik Yook
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source