Results 51 to 60 of about 1,354 (264)

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Novel Optimal Class of Eighth-Order Methods for Solving Nonlinear Equations and Their Dynamical Aspects [PDF]

Sahand Communications in Mathematical Analysis
In this paper, a novel optimal class of eighth-order convergence methods for finding simple roots of nonlinear equations is derived based on the Predictor-Corrector of Halley method.
Abdallah Dawoud, MAlak Khashoqji, Tareq Al-hussain, Ibrahim Al-Subaihi   +3 more
doaj   +1 more source

PREDICTOR–CORRECTOR SMOOTHING NEWTON METHOD FOR SOLVING SEMIDEFINITE PROGRAMMING [PDF]

Bulletin of the Australian Mathematical Society, 2009
AbstractThere has been much interest recently in smoothing methods for solving semidefinite programming (SDP). In this paper, based on the equivalent transformation for the optimality conditions of SDP, we present a predictor–corrector smoothing Newton algorithm for SDP. Issues such as the existence of Newton directions, boundedness of iterates, global
Wu, Caiying, Chen, Guoqing
openaire   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Insight into thermal dynamic of stagnated flow of MHD Jeffery fluid when the joule heating, viscous dissipation and Soret effect are present: A multistep Milne's approach

Case Studies in Thermal Engineering
The purpose of this work is to use the RK approach in conjunction with Milne's Predictor Corrector method to investigate the numerical solution of the magnetohydrodynamic Jeffery fluid passing over the upper horizontal parabolic surface.
Muhammad Awais, T. Salahuddin, Maawiya Ould Sidi, Afnan Al Agha, Hakim Al Garalleh   +4 more
doaj   +1 more source

An efficient numerical scheme for fractional model of HIV-1 infection of CD4+ T-cells with the effect of antiviral drug therapy

Alexandria Engineering Journal, 2020
In the present paper, a HIV-1 infection of CD4+ T-cells with the impact of drug treatment model of arbitrary order have been examined with the aid of Legendre wavelet operational matrix method.
Sunil Kumar, Ranbir Kumar, Jagdev Singh, K.S. Nisar, Devendra Kumar   +4 more
doaj   +1 more source

Milne’s Implementation on Block Predictor-corrector Methods

Journal of Applied Sciences, 2016
Milne’s implementation on block predictor-corrector methods for integration nonstiff ordinary differential equations is been considered. The introduction of Milne’s implementation attracts a lot of computational benefits, which guarantees step size variation, convergence criteria and error control.
Oghonyon, J. G., Okunuga, S. A., Iyase, S.A .   +2 more
openaire   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

The Implicit Phase-Fitted and Amplification-Fitted Four-Point Block Methods for Oscillatory First-Order Problems

Mathematics
This study introduces a family of implicit four-point block methods for solving first-order initial value problems (IVPs) with oscillatory solutions.
Nadiyah Hussain Alharthi, Anurag Kaur, Theodore E. Simos, Rubayyi T. Alqahtani   +3 more
doaj   +1 more source