Results 101 to 110 of about 8,804,924 (318)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Probability-Matching Predictors for Extreme Extremes [PDF]

open access: yes, 2013
A location- and scale-invariant predictor is constructed which exhibits good probability matching for extreme predictions outside the span of data drawn from a variety of (stationary) general distributions. It is constructed via the three-parameter {\mu,
McRobie, Allan
core  

iProEP: A Computational Predictor for Predicting Promoter

open access: yesMolecular Therapy: Nucleic Acids, 2019
Promoter is a fundamental DNA element located around the transcription start site (TSS) and could regulate gene transcription. Promoter recognition is of great significance in determining transcription units, studying gene structure, analyzing gene ...
Hong-Yan Lai   +6 more
semanticscholar   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Analysis of Clinical Characteristics and Poor Prognostic Predictors in Patients With an Initial Diagnosis of Autoimmune Encephalitis

open access: yesFrontiers in Immunology, 2019
Purpose: We aimed to retrospectively analyze the clinical features, laboratory and imaging results, and predictors of poor prognosis for patients with an initial diagnosis of autoimmune encephalitis (AE) at the Affiliated Hospital of Zunyi Medical ...
Xiaowei Qiu   +14 more
doaj   +1 more source

Investor sentiment aligned: : A powerful predictor of stock returns

open access: yes, 2015
We propose a new investor sentiment index that is aligned with the purpose of predicting the aggregate stock market. By eliminating a common noise component in sentiment proxies, the new index has much greater predictive power than existing sentiment ...
Dashan Huang   +3 more
semanticscholar   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

HONEYCOMBING AND DEFORMATION OF SIX WOOD SPECIES AND THEIR RELATIONSHIP WITH SEVERAL PHYSICAL

open access: yesJurnal Penelitian Hasil Hutan (Journal of Forest Products Research), 2017
It is presumed that the wood susceptibility to drying defects is related to several physical properties. This paper examines the drying defects: honeycombing and deformation of six wood species (trema, fast growing teak, bayur, jabon, angsana and lamtoro)
Karnita Yuniarti   +2 more
doaj   +1 more source

Estimation and prediction of road traffic flow using particle filter for real-time traffic control [PDF]

open access: yes, 2013
Real-data testing results of a real-time state estimator and predictor are presented with particular focus on the feature of enabling of detector fault alarms and also its relation to queue-length based traffic control.
Joelianto, Endra   +2 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Home - About - Disclaimer - Privacy