Results 121 to 130 of about 681,040 (233)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Diagnostic Delay and its Predictors among Tuberculosis Patients in Kandahar, Afghanistan: A Cross-sectional Analytical Study

International Journal of Mycobacteriology
Background: Diagnostic delay among tuberculosis (TB) patients leads to late anti-TB treatment initiation, which is associated with poor prognosis and increased TB transmission.
Hazratullah Bariz, Muhammad Haroon Stanikzai, Ghulam Mohayuddin Mudaser, Khalid Ahmad Stanikzai, Omid Dadras   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Sensors and Sensing Methods for Early Detection of Life-Threatening Sudden Illnesses in Motor Vehicles Drivers

Engineering Proceedings
Due to the increasing number of vehicles and the aging population, the vulnerability to sudden medical emergencies among drivers is a growing problem. Events such as heart attack, stroke, and loss of consciousness can occur without warning and endanger ...
Hristo Radev, Galidiya Petrova
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The pediatric supratentorial MYCN-amplified high-grade gliomas methylation class presents the same radiological, histopathological and molecular features as their pontine counterparts

Acta Neuropathologica Communications, 2020
A. Tauziède-Espariat, M-A Debily, D. Castel, J. Grill, S. Puget, A. Roux, R. Saffroy, M. Pagès, A. Gareton, F. Chrétien, E. Lechapt, V. Dangouloff-Ros, N. Boddaert, P. Varlet   +13 more
doaj   +1 more source

Six-Month Brain Health Outcomes in the Geriatric Population After Mild Traumatic Brain Injury: A Prospective Neuroimaging Study

Clinical and Translational Neuroscience
Introduction: Mild traumatic brain injury (mTBI) in older adults (≥65 years) is often underestimated, despite being associated with significant morbidity. Age-related vulnerability, comorbidities, and medication use may exacerbate outcomes.
Igor Horvat, Jagoš Golubović, Djula Djilvesi, Bojan Jelača, Petar Vuleković   +4 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Empathy and Its Predictive Factors in Undergraduate Health Professional Students: A Longitudinal Cohort Study

Nursing Reports
Background: Empathy is essential for enhancing care quality, making its understanding and predictors crucial for healthcare education. Objective: To investigate empathy evolution and its predictors among first-year health professional students at a ...
Valeria Caponnetto, Elona Gaxhja, Ilda Taka, Elona Prifti, Vittorio Masotta, Ilaria Paoli, Loreto Lancia, Angelo Dante, Cristina Petrucci   +8 more
doaj   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source