Results 111 to 120 of about 681,040 (233)
Personification of the approaches to reperfusion therapy of ischemic stroke
Анналы клинической и экспериментальной неврологии, 2017 Introduction. Systemic thrombolytic therapy using recombinant tissue plasminogen activator (rtPA) is the gold standard of reperfusion therapy in certainpatients with ischemic stroke during the first 4.5 h after stroke onset. Objective.
Maksim A. Domashenko +5 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Least angle regression for time series forecasting with many predictors. [PDF]
Least Angle Regression(LARS)is a variable selection method with proven performance for cross-sectional data. In this paper, it is extended to time series forecasting with many predictors. The new method builds parsimonious forecast models,taking the time
Croux, Christophe, Gelper, Sarah
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Frontiers in ImmunologyPurposeThis study assessed the predictive value of dynamic laboratory parameter changes before and after intravenous immunoglobulin (IVIG) treatment for IVIG resistance in children with Kawasaki disease (KD).MethodsChildren with KD were stratified based ...
Zhiyuan Liu +14 more
doaj +1 more source
Inference about predictive ability when there are many predictors [PDF]
We enhance the theory of asymptotic inference about predictive ability by considering the case when a set of variables used to construct predictions is sizable.
Stanislav Anatolyev
core
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
CLINICAL AND X-RAY SPECIFICS OF SARCOIDOSIS DETECTED IN TUBERCULOSIS CONTROL SERVICES
Туберкулез и болезни лёгких, 2015 The current diffculties of differential diagnostics of pulmonary sarcoidosis have been analyzed in 58 patients. The duration of the diagnostic period has been described.
Zh. A. Laushkina +2 more
doaj
The heterogeneous life space trajectories and predictors in stroke patients: a cohort study
Frontiers in NeurologyObjectiveThis study aimed to identify heterogeneous trajectories of life space among stroke patients and explore the predictors for different classes of life space.MethodsThis prospective cohort study assessed 210 stroke patients’ life space at baseline ...
Bei Yang +6 more
doaj +1 more source