Results 91 to 100 of about 985,541 (248)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Value of dynamic changes in inflammatory biomarkers for predicting intravenous immunoglobulin resistance in children with Kawasaki disease

Frontiers in Immunology
PurposeThis study assessed the predictive value of dynamic laboratory parameter changes before and after intravenous immunoglobulin (IVIG) treatment for IVIG resistance in children with Kawasaki disease (KD).MethodsChildren with KD were stratified based ...
Zhiyuan Liu, Yidan Zhang, PanPan Liu, Weiguo Qian, Qiuqin Xu, Miao Hou, Ying Liu, Guanghui Qian, Jiajia Tan, Qianzi Ge, Mingyang Zhang, Jing Li, Sheng Zhao, Haitao Lv, Shuhui Wang   +14 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

CLINICAL AND X-RAY SPECIFICS OF SARCOIDOSIS DETECTED IN TUBERCULOSIS CONTROL SERVICES

Туберкулез и болезни лёгких, 2015
The  current diffculties of  differential diagnostics of  pulmonary sarcoidosis have been analyzed in  58 patients. The  duration of the diagnostic period has been described.
Zh. A. Laushkina, V. A. Krasnov, P. N. Filimonov   +2 more
doaj  

The heterogeneous life space trajectories and predictors in stroke patients: a cohort study

Frontiers in Neurology
ObjectiveThis study aimed to identify heterogeneous trajectories of life space among stroke patients and explore the predictors for different classes of life space.MethodsThis prospective cohort study assessed 210 stroke patients’ life space at baseline ...
Bei Yang, Bei Yang, Rui Xie, Siyuan Ge, Ruixue Tang, Kangyao Cheng, Yin Wang   +6 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Diagnostic Delay and its Predictors among Tuberculosis Patients in Kandahar, Afghanistan: A Cross-sectional Analytical Study

International Journal of Mycobacteriology
Background: Diagnostic delay among tuberculosis (TB) patients leads to late anti-TB treatment initiation, which is associated with poor prognosis and increased TB transmission.
Hazratullah Bariz, Muhammad Haroon Stanikzai, Ghulam Mohayuddin Mudaser, Khalid Ahmad Stanikzai, Omid Dadras   +4 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

The pediatric supratentorial MYCN-amplified high-grade gliomas methylation class presents the same radiological, histopathological and molecular features as their pontine counterparts

Acta Neuropathologica Communications, 2020
A. Tauziède-Espariat, M-A Debily, D. Castel, J. Grill, S. Puget, A. Roux, R. Saffroy, M. Pagès, A. Gareton, F. Chrétien, E. Lechapt, V. Dangouloff-Ros, N. Boddaert, P. Varlet   +13 more
doaj   +1 more source

Sensors and Sensing Methods for Early Detection of Life-Threatening Sudden Illnesses in Motor Vehicles Drivers

Engineering Proceedings
Due to the increasing number of vehicles and the aging population, the vulnerability to sudden medical emergencies among drivers is a growing problem. Events such as heart attack, stroke, and loss of consciousness can occur without warning and endanger ...
Hristo Radev, Galidiya Petrova
doaj   +1 more source