Results 71 to 80 of about 23,377 (228)

Optical Control of the Glucocorticoid Receptor Activity With a Photoswitchable Agonist

Angewandte Chemie, EarlyView.
A photoswitchable glucocorticoid receptor agonist enables optical control of receptor activity, achieving picomolar potency and partial agonism that preferentially maintains anti‐inflammatory signaling over canonical transcriptional activation. ABSTRACT Glucocorticoids (GCs) are widely prescribed anti‐inflammatory agents whose clinical utility is ...
Zoe Sessions, Chloé Van Leene, Dorien Clarisse, George Keen, Agnė Šveistytė, Dinahlee Saturnino Guarino, Robert H. Mach, Karolien De Bosscher, Dirk Trauner   +8 more
wiley   +2 more sources

Δ1-Dehydrogenation and C20 Reduction of Cortisone and Hydrocortisone Catalyzed by Rhodococcus Strains

Molecules, 2020
Prednisone and prednisolone are steroids widely used as anti-inflammatory drugs. Development of the pharmaceutical industry is currently aimed at introducing biotechnological processes and replacing multiple-stage chemical syntheses.
Stefania Costa, Federico Zappaterra, Daniela Summa, Bruno Semeraro, Giancarlo Fantin   +4 more
doaj   +1 more source

Low-dose modified-release prednisone in axial spondyloarthritis: 3-month efficacy and tolerability

, 2016
Francesca Bandinelli,1 Francesco Scazzariello,1 Emanuela Pimenta da Fonseca,2 Mittermayer Barreto Santiago,2 Claudio Marcassa,3 Francesca Nacci,1 Marco Matucci Cerinic1 1Department of Experimental and Clinical Medicine, University of Florence, Florence,
Bandinelli F, Nacci F, Matucci Cerinic M, Scazzariello F, Barreto Santiago M, Pimenta da Fonseca E, Marcassa C   +6 more
core  

Associations of Frailty With the Risk of Incident Cancer and Cancer‐Related Mortality in Veterans With Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective This study investigated the association between frailty and cancer incidence and mortality in patients with rheumatoid arthritis (RA). It aimed to identify how frailty influences cancer risk and cancer‐specific outcomes. Methods This retrospective cohort study analyzed data from the Veterans’ Affairs Rheumatoid Arthritis Registry (2002–2023).
Bhavik Bansal, Aaron Baraff, Katherine Wysham, James S. Andrews, Bryant R. England, Ted R. Mikuls, Joshua Baker, Kaleb Michaud, Alexa Meara, Una Makris, Carolyn Presley, Ariela Orkaby, Namrata Singh   +12 more
wiley   +1 more source

Cost-effectiveness of modified-release prednisone in the treatment of moderate to severe rheumatoid arthritis with morning stiffness based on directly elicited public preference values

, 2013
William Dunlop,1 Itrat Iqbal,1 Ifty Khan,2 Mario Ouwens,3 Louise Heron4 1Mundipharma International Limited, Cambridge, 2University College London, London, United Kingdom; 3Mapi HEOR, Houten, The Netherlands; 4Adelphi Values, Macclesfield, Cheshire ...
Khan I, Dunlop W, Iqbal I, Heron L, Ouwens M   +4 more
core  

Corticosteroid switch after progression on abiraterone acetate plus prednisone [PDF]

, 2020
Introduction: Abiraterone acetate plus prednisone is approved in metastatic castration-resistant prostate cancer. There is some evidence in favour of the steroid switch from prednisone to dexamethasone in patients who progressed whilst on abiraterone ...
D'Angelo, Alberto, Corona, Silvia Paola, Roviello, Giandomenico, Roviello G., Corona S., Sobhani N., D'Angelo A., Sobhani, Navid   +7 more
core   +1 more source

Incidence, Risk Factors and Management of Adverse Events in Contemporary Real‐World Care of Children with Juvenile Idiopathic Arthritis

Arthritis Care &Research, Accepted Article.
Objective We describe the frequency, risk factors, severity, and management of actionable and serious adverse events (AAE and SAE) in children with newly diagnosed Juvenile Idiopathic Arthritis (JIA) in Canada. Methods We enrolled patients within 3 months of JIA diagnosis in the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry,
Bashayer Alnuaimi, Roberta A. Berard, Jean‐Philippe Proulx‐Gauthier, Heinrike Schmeling, Michelle Batthish, Gilles Boire, Adam M. Huber, Dax G. Rumsey, Jaime Guzman, Gaëlle Chédeville, The CAPRI registry Investigators   +10 more
wiley   +1 more source

Metabolic Profiling Reveals an Abnormal Pattern of Serum Fatty Acids in MRL/lpr Mice Under Treatment With Prednisone

Frontiers in Pharmacology, 2020
Glucocorticoids (GCs) are commonly used to treat systemic lupus erythematosus (SLE). Unfortunately, excessive GCs can induce many side effects associated with disordered fatty acid (FA) metabolism.
Qianqian Li, Jia Zhou, Dingyi Zhang, Xiafeng Zhang, Zhenghao Xu, Dehong Wu   +5 more
doaj   +1 more source

Prevalence of Dietary Supplement Use and Potential Medication Interactions Among Adults with Systemic Lupus Erythematosus

Arthritis Care &Research, Accepted Article.
Objective To characterize the prevalence and correlates of dietary supplement use, identify commonly used supplements, and evaluate potential supplement–medication interactions among adults with systemic lupus erythematosus (SLE). Methods We analyzed cross‐sectional data from 451 adults in the Approaches to Positive, Patient‐centered Experiences of ...
Sarah L. Patterson, Russell Ellyson, Jessica Fitzpatrick, Ghizlane Yaakoubi, Bradley Pearce, S. Sam Lim, Jinoos Yazdany, Laura C. Plantinga   +7 more
wiley   +1 more source

Efficacy of leflunomide combined with prednisone for the treatment of PLA2R-associated primary membranous nephropathy

Renal Failure, 2020
Objective To evaluate the clinical efficacy and safety of leflunomide (LEF) combined with prednisone for the treatment of PLA2R-associated primary membranous nephropathy (PMN) and changes in anti-PLA2R antibody titers after treatment.
Yaling Guo, Xueping Wu, Lei Liu, Haifeng Zhang, Lijuan Yang, Weidong Chen   +5 more
doaj   +1 more source