Results 51 to 60 of about 117,571 (283)

Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth

Advanced Science, EarlyView.
Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang, Emilie Derisoud, Denise Parreira, Nayere Taebnia, Paulo R. Jannig, Reza Zandi Shafagh, Allan Zhao, Congru Li, Macarena Ortiz, Manuel Alejandro Maliqueo, Elisabet Stener‐Victorin, Volker M. Lauschke, Qiaolin Deng   +12 more
wiley   +1 more source

Is postpartum preeclampsia a continuation of intrapartum preeclampsia? Maternal risk factors in intrapartum vs. postpartum preeclampsia: a retrospective cohort study

BMC Pregnancy and Childbirth
Objective To compare maternal characteristics and risk factors associated with intrapartum and postpartum preeclampsia in relation to pregnancies without preeclampsia.
Hila Shalev-Ram, Talish Razi, Dorit Ravid, Hezzy Shmueli, Ronen Arbel, Tal Biron-Shental   +5 more
doaj   +1 more source

Placental Growth Factor Levels in Preeclampsia Compared to Normal Pregnancy

Indonesian Journal of Obstetrics and Gynecology, 2015
Objective: To identify and analyze the differences in the levels of PlGF in preeclampsia and normal pregnancy. Method: This was a cross-sectional observational qualitative study of PlGF in preeclampsia and normal pregnancy. The number of samples in
Dumaria Situmorang, Hermie MM Tendean, John J Wantania   +2 more
doaj   +1 more source

Optic nerve sheath diameter in severe preeclampsia with neurologic features versus controls

BMC Pregnancy and Childbirth, 2022
Background Optic nerve sheath diameters (ONSD) have been validated as an accurate screening tool to detect elevated intracranial pressure in hypertensive encephalopathy.
Mary E. Sterrett, Brittany Austin, Ryan M. Barnes, Eugene Y. Chang   +3 more
doaj   +1 more source

Preeclampsia Across Pregnancies and Associated Risk Factors: Findings From a High‐Risk US Birth Cohort

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Preeclampsia increases women's risks for maternal morbidity and future cardiovascular disease. The aim of this study was to identify opportunities for prevention by examining the association between cardiometabolic risk factors and ...
S. Michelle Ogunwole, George Mwinnyaa, Xiaobin Wang, Xiumei Hong, Janice Henderson, Wendy L. Bennett   +5 more
doaj   +1 more source

HRS Degradation‐Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal‐Fetal Immune Homeostasis

Advanced Science, EarlyView.
This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei, Yuhan Lin, Xiu Liu, Xiaohong Zhu, Xiaowen Lu, Zhan Shi, Fan Jia, Shiqian Xu, Ling Fang, Lingling Jiang, Songying Zhang   +10 more
wiley   +1 more source

Preeclampsia prevention

Colombia Medica, 2016
Colombia and Brazil are developing countries where pregnancy-related hypertensive disorders and associated conditions constitute major concerns in public health area. Calcium plus conjugated linoleic acid used by pregnant adolescents had preventive effect on PE, but the prevention did not occur with utilization of calcium alone. After implementation of
openaire   +3 more sources

Metabolic Reprogramming Driven by Trophoblasts and Decidual XCR1+PMN‐MDSC Crosstalk Controls Adverse Outcomes Associated With Advanced Maternal Age

Advanced Science, EarlyView.
The interaction between trophoblasts and decidual polymorphonuclear myeloid‐derived suppressor cells (dPMN‐MDSCs) via the XCL1–XCR1 axis is crucial for fetal development during the third trimester. Disruption of this axis impairs FOXO1 activity and causes metabolic imbalance in dPMN‐MDSCs, contributing to adverse outcomes associated with advanced ...
Meiqi Chen, Yuxiong Guo, Qing Zhao, Jingping Liu, Shuyi Kuang, Zhengcong Huang, Chenlin Lv, Shuxiu Xu, Zekai Zhuang, Anyan Yang, Jing Li, Kai Wu, Yumei He   +12 more
wiley   +1 more source

Inherited factors contribute to an inverse association between preeclampsia and breast cancer

Breast Cancer Research, 2018
Background Preeclampsia is frequently linked to reduced breast cancer risk. However, little is known regarding the underlying genetic association and the association between preeclampsia and mammographic density.
Haomin Yang, Wei He, Mikael Eriksson, Jingmei Li, Natalie Holowko, Flaminia Chiesa, Per Hall, Kamila Czene   +7 more
doaj   +1 more source

Uric acid as a mediator in the correlation between white blood cells and preeclampsia severity: a retrospective cohort study

Scientific Reports, 2023
This study aimed to analyze the independent risk factors for predicting preeclampsia severity and explore its underlying mechanism. Clinical data of patients with preeclampsia were collected from the Medical Information Mart for Intensive Care (MIMIC)-IV
Bai-jia Li, Ting-ting Zhu, Xiao-ying Hu, Chao-man He   +3 more
doaj   +1 more source