Results 91 to 100 of about 25,563,837 (296)

Using Rasch analysis to form plausible health states amenable to valuation: the development of CORE-6D from CORE-OM in order to elicit preferences for common mental health problems [PDF]

Purpose: To describe a new approach for deriving a preference-based index from a condition specific measure that uses Rasch analysis to develop health states.
Barkham, M, Brazier, JE, Mavranezouli, I, Young, Tracey A.   +3 more
core  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Estimation of a preference based single index from the sexual quality of life questionnaire (SQOL) using ordinal data [PDF]

There is increasing interest in using ordinal methods to estimate cardinal values for health states to calculate quality adjusted life years. This paper reports the estimation of models of rank data and discrete choice experiment (DCE) data to derive a ...
Ratcliffe, J, Tsuchiya, A, Brazier, J, Symonds, T, Brown, M   +4 more
core  

E-QALY: face validity testing the items for a new generic preference-based measure

, 2020
Carlton J, Connell J, Peasgood T, et al. E-QALY: face validity testing the items for a new generic preference-based measure. Quality of Life Research.
Monteiro, Andrea, Kuharic, Maja, Ludwig, Kristina, Peasgood, Tessa, Marten, Ole ; https://orcid.org/, Kreimeier, Simone ; https://orcid.org/, Rodriguez, Rocio, Yang, Zhihao, Pickard, A. Simon, Augustovski, Federico, Greiner, Wolfgang, Carlton, Jill, Engel, Lidia, Mulhern, Brendan, Luo, Nan, Connell, Janice, Belizan, Maria, Mukuria, Clara   +17 more
core  

Closeness Preference - A New Interestingness Measure for Sequential Rules Mining

, 2013
International audienceThe time-interval between the antecedent and the consequent of a sequential rule can be considered as an important aspect in sequential rules interest.
Lenca, Philippe, Railean, Ion, Moga, Sorin, Borda, Monica   +3 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Sample sizes for the SF-6D preference based measure of health from the SF-36: a practical guide [PDF]

Background Health Related Quality of Life (HRQoL) measures are becoming more frequently used in clinical trials and health services research, both as primary and secondary endpoints.
Walters, SJ, Brazier, JE
core  

E-QALY: psychometric testing and selecting the items for a new generic preference-based measure

, 2020
Peasgood T, Mukuria C, Marten O, et al. E-QALY: psychometric testing and selecting the items for a new generic preference-based measure. Quality of Life Research .
Gibbons, Luz, Monteiro, Andrea, Kuharic, Maja, Peasgood, Tessa, Marten, Ole ; https://orcid.org/, Kreimeier, Simone ; https://orcid.org/, Yang, Zhihao, Augustovski, Federico, Greiner, Wolfgang, Engel, Lidia, Mulhern, Brendan, Pickard, Simon, Luo, Nan, Brazier, John, Belizan, Maria, Mukuria, Clara   +15 more
core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

China Health Related Outcomes Measures (CHROME): Development of a New Generic Preference-Based Measure for the Chinese Population. [PDF]

Pharmacoeconomics, 2022
Wu J, He X, Chen P, Xie S, Li X, Hu H, Zhao K, Xie F, CHROME Study Group.   +8 more
europepmc   +1 more source