Results 101 to 110 of about 1,368,837 (297)

Cardinal Scales for Public Health Evaluation [PDF]

Policy studies often evaluate health for a population by summing the individuals’ health as measured by a scale that is ordinal or that depends on risk attitudes.
Charles M. Harvey, Lars Peter Østerdal
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

China Health Related Outcomes Measures (CHROME): Development of a New Generic Preference-Based Measure for the Chinese Population. [PDF]

Pharmacoeconomics, 2022
Wu J, He X, Chen P, Xie S, Li X, Hu H, Zhao K, Xie F, CHROME Study Group.   +8 more
europepmc   +1 more source

Using Rasch analysis to form plausible health states amenable to valuation: the development of CORE-6D from CORE-OM in order to elicit preferences for common mental health problems [PDF]

Purpose: To describe a new approach for deriving a preference-based index from a condition specific measure that uses Rasch analysis to develop health states.
Barkham, M, Brazier, JE, Mavranezouli, I, Young, Tracey A.   +3 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Understanding Trust [PDF]

Several papers study the effect of trust by using the answer to the World Values Survey (WVS) question "Generally speaking, would you say that most people can be trusted or that you can't be too careful in dealing with people?" to measure the level of ...
Anna Toldra, Luigi Zingales, Paola Sapienza   +2 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Criteria for item selection for a preference-based measure for use in economic evaluation. [PDF]

Qual Life Res, 2021
Peasgood T, Mukuria C, Carlton J, Connell J, Brazier J.   +4 more
europepmc   +1 more source

The dynamics of consensus in group decision making: investigating the pairwise interactions between fuzzy preferences. [PDF]

In this paper we present an overview of the soft consensus model in group decision making and we investigate the dynamical patterns generated by the fundamental pairwise preference interactions on which the model is based.
Mario Fedrizzi, Matteo Brunelli, Michele Fedrizzi, Ricardo Alberto Marques Pereira   +3 more
core  

Deriving a preference-based measure for cancer using the EORTC QLQ-C30 : a confirmatory versus exploratory approach [PDF]

, 2012
Background: To derive preference-based measures from various condition-specific descriptive health-related quality of life (HRQOL) measures. A general 2-stage method is evolved: 1) an item from each domain of the HRQOL measure is selected to form a ...
Aaronson, Neil K., Costa, Daniel S.J., Fayers, Peter M., Grimison, Peter S., Janda, Monika, King, Madeline T., Pallant, Julie F., Rowen, Donna, Velikova, Galina, Viney, Rosalie, Young, Tracey A.   +10 more
core   +1 more source