Results 111 to 120 of about 104,275,366 (301)
On quasistability radius of a vector trajectorial problem with a principle of optimality generalizing Pareto and lexicographic principles [PDF]
Computer Science Journal of Moldova, 2005 A multicriterion linear combinatorial problem with a parametric principle of optimality is considered. This principle is defined by a partitioning of partial criteria onto Pareto preference relation groups within each group and the lexicographic ...
Sergey E. Bukhtoyarov +1 more
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
On a Generalization of Markowitz Preference Relation
, 2015 Given two families of continuous functions $u$ and $v$ on a topological space $X$, we define a preorder $R=R(u,v)$ on $X$ by the condition that any member of $u$ is an $R$-increasing and any member of $v$ is an $R$-decreasing function. It turns out that if the topological space $X$ is quasi-compact and sequentially compact, then any element of $X$ is ...
openaire +3 more sources
Preferences in Temporal Relational Databases
IEEE AccessDespite the huge amount of work devoted to the treatment of time within the relational context, some relevant phenomena remain to be fully addressed. We focus on one of them, i.e., temporal indeterminacy with preferences. In several domains (e.g., workflows, guidelines) and tasks (e.g., planning, scheduling), the exact time of occurrence of facts is ...
Luca Anselma, Paolo Terenziani
openaire +5 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Journal of Numerical Analysis and Approximation Theory, 2006 multicriteria linear combinatorial problem is considered, principle of optimality of which is defined by a partitioning of partial criteria onto groups with Slater preference relation within each group and the lexicographic preference relation ...
Vladimir A. Emelichev +1 more
doaj +2 more sources
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Eigenvector Procedure based on Weighted Preference Flows in Multicriteria Outranking Analysis [PDF]
The outranking analysis has been frequently used to deal with the complex decisions involving qualitative criteria and imprecise data. So far, various versions of ELECTRE have been proposed for ranking alternatives in the outranking analysis.
Eiji Takeda, Santha Chenayah
core
The class of opportunity filters and the preference revealed by a path independent choice function [PDF]
Nova Economia, 2004 The purpose of this paper is to replicate the theory developed by Gekker (2001), without using any monotonicity assumption. We however retain a non-triviality assumption implicit in Gekker (2001), which says that there is at least one opportunity set ...
Somdeb Lahiri
doaj
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source