Results 121 to 130 of about 1,233,746 (351)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Incorporating Patient Preferences in the Management of Multiple Long-Term Conditions: Is This a Role for Clinical Practice Guidelines?

Journal of Comorbidity, 2015
Background Clinical practice guidelines provide an evidence-based approach to managing single chronic conditions, but their applicability to multiple conditions has been actively debated.
Charlotte E. Young, Frances M. Boyle, Katie S. Brooker, Allyson J. Mutch   +3 more
doaj   +1 more source

Beyond Abundance: Self-Interest Motives for Sustainable Consumption in Relation to Product Perception and Preferences [PDF]

, 2010
Anne Marchand, Stuart Walker, Tim Cooper
openalex   +1 more source

Measurement Theory and the Foundations of Utilitarianism [PDF]

Harsanyi used expected utility theory to provide two axiomatizations of weighted utilitarian rules. Sen (and later, Weymark) has argued that Harsanyi has not, in fact, axiomatized utilitarianism because he has misapplied expected utility theory ...
John a. Weymark
core  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

About one discrete analog of Hausdorff semi-continuity of suitable mapping in a vector combinatorial problem with a parametric principle of optimality ("from Slater to lexicographic")

Journal of Numerical Analysis and Approximation Theory, 2006
multicriteria linear combinatorial problem is considered, principle of optimality of which is defined by a partitioning of partial criteria onto groups with Slater preference relation within each group and the lexicographic preference relation ...
Vladimir A. Emelichev, Andrey A. Platonov   +1 more
doaj   +2 more sources

A note on representation of references. [PDF]

We consider a class of relations which includes irreflexive preference relations and interdependent preferences. For this class, we obtain necessary and sufficient conditions for representation of the relation by two numerical functions in the sense of ...
Estévez Toranzo, Margarita, García Cutrín, Javier, Hervés Beloso, Carlos, López López, Miguel A.   +3 more
core  

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Core Rationalizability in Two-Agent Exchange Economies [PDF]

We provide a characterization of selection correspondences in two-person exchange economies that can be core rationalized in the sense that there exists a preference profile with some standard properties that generates the observed choices as the set of ...
Bossert, Walter, Sprumont, Yves
core