Results 101 to 110 of about 1,233,746 (351)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

Revision of conjectures about the opponent's utilities in signaling games. [PDF]

open access: yes
In this paper we apply the concept of preference conjecture equilibrium introduced in Perea (2003) to signaling games and show its relation to sequential equilibrium. Furthermore, we introduce the concept of minimum revision equilibrium and show how this
Perea,Andres   +3 more
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Probabilistic sophistication and multiple priors. [PDF]

open access: yes
We show that under fairly mild conditions, a maximin expected utility preference relation is probabilistically sophisticated if and only if it is subjective expected utility.
Massimo Marinacci
core  

INVERSE RELATIONS BETWEEN PREFERENCE AND CONTRAST [PDF]

open access: yesJournal of the Experimental Analysis of Behavior, 1992
Pigeons were trained on a multiple schedule in which two target components with identical reinforcement schedules were followed by either the same‐valued schedule or by extinction. Response rate increased in both target components but was higher in the target component followed by extinction, replicating previous findings of positive anticipatory ...
openaire   +2 more sources

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

open access: yesFEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth   +6 more
wiley   +1 more source

On quasistability radius of a vector trajectorial problem with a principle of optimality generalizing Pareto and lexicographic principles [PDF]

open access: yesComputer Science Journal of Moldova, 2005
A multicriterion linear combinatorial problem with a parametric principle of optimality is considered. This principle is defined by a partitioning of partial criteria onto Pareto preference relation groups within each group and the lexicographic ...
Sergey E. Bukhtoyarov   +1 more
doaj  

SHOULD THE UTILITY FUNCTION BE DITCHED? [PDF]

open access: yes
This note takes a retrospective look at the Utility Construct still in use in economic science and compares it to a new approach based on recent findings in neuroscience.
Dominique, C-Rene
core   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

open access: yesFEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa   +2 more
wiley   +1 more source

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