Results 111 to 120 of about 586 (172)
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The Journal of Steroid Biochemistry and Molecular Biology, 2008
In this study, we report the synthesis and biological evaluation of several new 3-substituted pregna-4,16-diene-6,20-dione derivatives (11a-11d). These compounds were prepared from the commercially available 16-dehydropregnenolone acetate. The biological effect of these steroids was demonstrated in in vivo and in vitro experiments.
Sergio Recillas +4 more
openaire +3 more sources
In this study, we report the synthesis and biological evaluation of several new 3-substituted pregna-4,16-diene-6,20-dione derivatives (11a-11d). These compounds were prepared from the commercially available 16-dehydropregnenolone acetate. The biological effect of these steroids was demonstrated in in vivo and in vitro experiments.
Sergio Recillas +4 more
openaire +3 more sources
Guggulsterone for Chemoprevention of Cancer.
Current pharmaceutical design, 2015Guggulsterone [4, 17(20)-pregnadiene-3, 16-dione] is a plant sterol derived from the gum resin of the tree Commiphora wightii. The gum resin of the guggul tree has been used in traditional medicine for centuries to treat obesity, liver disorders ...
S. Shishodia +3 more
semanticscholar +1 more source
New Polyhydroxylated Pregnadienes from the South African Soft Coral Pieterfaurea unilobata
Journal of Natural Products, 1997Seven pregnadiene metabolites, pregna-5,20-diene-3α,7α-diol 3α-acetate (1), pregna-5,20-diene-3β,7α-diol 7α-acetate (2), pregna-5,20-dien-3β-ol (3), pregna-5,20-diene-3α,7α,11α-triol 3α-acetate (4), pregna-5,20-diene-3α,7α, 11α-triol 3α,7α-diacetate (5), pregna-5,20-diene-3α,7α,19-triol 30, 19-diacetate (6), and pregna-5,20-diene-3α,7α,11α,19-tetrol 3α,
Denzil R. Beukes +4 more
openaire +2 more sources
Endocrinology, 1979
Modifications in the concentration of progestinbinding sites (PR) in rat hypothalamus and pituitary, measured with [3H]R5020 (promegestone, 17,21-dimethyl-19-nor-4,9-pregnadiene-3,20-dione) have been related to the facilitative and inhibitory actions of ...
M. Moguilewsky, J. Raynaud
semanticscholar +1 more source
Modifications in the concentration of progestinbinding sites (PR) in rat hypothalamus and pituitary, measured with [3H]R5020 (promegestone, 17,21-dimethyl-19-nor-4,9-pregnadiene-3,20-dione) have been related to the facilitative and inhibitory actions of ...
M. Moguilewsky, J. Raynaud
semanticscholar +1 more source
ChemistryOpen
22-Hydroxy-23,24-bisnorchol-4-ene-3-one (4-HBC) and 3-oxo-4,17-pregnadiene-20-carboxylic acid methyl ester (PDCE) are useful precursors for the synthesis of steroidal active pharmaceutical ingredients.
Xuemei Li +8 more
semanticscholar +1 more source
22-Hydroxy-23,24-bisnorchol-4-ene-3-one (4-HBC) and 3-oxo-4,17-pregnadiene-20-carboxylic acid methyl ester (PDCE) are useful precursors for the synthesis of steroidal active pharmaceutical ingredients.
Xuemei Li +8 more
semanticscholar +1 more source
Endocrinology, 1965
A reliable laboratory assay for rapidly quantitating the topical anti-inflammatory efficacy of steroids has been established. Croton oil, applied topically to the rat ear, elicited an acute phlogistic response which could be quantitated by removal and ...
G. Tonelli, L. Thibault, I. Ringler
semanticscholar +1 more source
A reliable laboratory assay for rapidly quantitating the topical anti-inflammatory efficacy of steroids has been established. Croton oil, applied topically to the rat ear, elicited an acute phlogistic response which could be quantitated by removal and ...
G. Tonelli, L. Thibault, I. Ringler
semanticscholar +1 more source
Response of rat ventral prostate to a new and novel 5 alpha-reductase inhibitor.
Endocrinology, 198117β-N,N-Diethylcarbamoyl-4-methyl-4-aza-5αandrostan-3-one (4-MA) strongly inhibits the 5α-reductase-mediated conversion of testosterone (T) to 5α-dihydrotestosterone [17β-hydroxy-5α-androstan-3-one (DHT)] both in vitro and in vivo.
J. R. Brooks +10 more
semanticscholar +1 more source
Crystal and molecular structure of 17α‐acetoxy‐21‐hydroxy‐1,4‐pregnadiene‐3,20‐dione
Crystal Research and Technology, 1990AbstractThe title compound 17α‐acetoxy‐21‐hydroxy‐1,4‐pregnadiene‐3,20‐dione crystallizes in the orthorhombic space group P 212121 with four molecules in the unit cell and the lattice parameters a = 10.950, b = 11.857, c = 15.634 Å. The crystal structure was determined by direct methods and refined by full matrix least squares calculations up to the ...
K. Simon +4 more
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Cytokine inhibition by a novel steroid, mometasone furoate.
Immunopharmacology and immunotoxicology, 1991Mometasone furoate (9 alpha, 21 dichloro-11 beta, 17 alpha dihydroxy-16 alpha methyl-1,4 pregnadiene-3, 20 dione-17-[2'] furoate) was an unexpectedly potent inhibitor of the in vitro production of three inflammatory cytokines, IL-1(1), IL-6, and TNF ...
B. Barton +3 more
semanticscholar +1 more source
Structure of 6-methyl-3,20-dioxo-4,6-pregnadien-17?-yl acetate, C24H32O4
Journal of Crystallographic and Spectroscopic Research, 1992The X-ray structure of 6-methyl-3,20-dioxo-4,6-pregnadien-17α-yl acetate is reported. The crystals are monoclinic, space groupP21,Z=4,a=28.955(7),b=6.597(2),c=11.064(3) A,/gb=90.80(2) °. The two crystallographically independent molecules have very similar overall geometries.
Zdzisław Gałdecki +5 more
openaire +2 more sources