Results 121 to 130 of about 586 (172)

Pharmacokinetic features of difluprednate ophthalmic emulsion in rabbits as determined by glucocorticoid receptor-binding bioassay.

Journal of Ocular Pharmacology and Therapeutics, 2011
PURPOSE Difluprednate (6α,9-difluoro-11β,17,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-acetate 17-butyrate, DFBA) has long been used as an anti-inflammatory dermatological agent.
T. Tajika, M. Waki, M. Tsuzuki, T. Kida, H. Sakaki   +4 more
semanticscholar   +1 more source

A New Method of Preparing the High Explosive RDX

, 1949
cisand tr~lzs-A~*~7-Pregnadiene-3 @,20-diol Diacetates (VII, VIII) .-A solution of 4.4 g. of A6-pregnene-3@-ol-20one and 2.45 g. of p-toluenesulfonic acid in 500 cc. of acetic anhydride was boiled gently and the solvent allowed to distil.
W. Bachmann, J. C. Sheehan
semanticscholar   +1 more source

Effects of progestins on sexual behaviour in castrated lizards (Cnemidophorus inornatus).

Journal of Endocrinology, 1988
In many male vertebrates, androgens stimulate, while progesterone inhibits, sexual behaviour. Testicular androgens also control sexual behaviour in males of the lizard Cnemidophorus inornatus. However, administration of progesterone will reinstate sexual
Jonathan Lindzey, David Crews
semanticscholar   +1 more source

Steroid receptor content in cytosol from normal and hyperplastic human prostates.

Journal of Clinical Endocrinology and Metabolism, 1979
Analyses of steroid hormone receptors were performed using a dextran-coated charcoal technique in cytosolic preparations from 40 cases of benign prostatic hyperplasia (BPH) and 10 normal human prostates.
P. Ekman, M. Snochowski, E. Dahlberg, D. Bression, B. Högberg, J. Gustafsson   +5 more
semanticscholar   +1 more source

Synthesis and Evaluation of Some Novel Pregnane Derivatives as Anti-Hyperlipidemic and Anti-Oxidant Agents

Letters in Organic Chemistry, 2018
In the present paper, synthesis of few novel pregnane derivatives and their evaluation as potential anti-hyperlipidemic and anti-oxidant agents has been reported. The synthesis of 3β-hydroxy- 16α-methoxy pregn-5-en-20-one (4) was achieved by reaction of
A. Sethi, Akriti Bhatia, R. Singh, A. Srivastava   +3 more
semanticscholar   +1 more source

Reduction of 17.alpha.-hydroxy-20-keto steroids: convenient synthesis of (E)-3.beta.-hydroxy-5,17(20)-pregnadiene 3-pivaloate and (Z)-3.beta.,16.alpha.-dihydroxy-5,17(20)-pregnadiene 3-pivaloate

The Journal of Organic Chemistry, 1990
Reduction of the 20-keto group of both 17α-hydroxy- and 16α~alkoxy-17α-hydroxy steroids has been examined with various hydride reagents in a number of different solvent sytems. For each of these steroids, specific conditions have been established to cleanly reduce to (20R)-17α,20-α-diols.
Masato Koreeda, Brian K. Shull
openaire   +2 more sources

THE COMPARATIVE ACTIVITIES OF Δ^1,4PREGNADIENE-21-OL-3,20-DIONE ACETATE AND DESOXYCORTICOSTERONE ACETATE IN THE RAT¹

Endocrinology, 1955
UNSATURATION of the 1:2 linkage of the cortical steroids has been reported to modify their pharmacologies properties. Thus the compounds Δ1,4 Pregnadiene-17α,21-diol-3,11–20-trione and Δ1,4-Pregnadiene- 11β,17α,21-triol-3,20-dione, respectively analogues of cortisone and hydrocortisone (Herzog et al., 1955), have greater adrenocortical, antirheumatic ...
A. C. Corcoran, Georges M. C. Masson, R. C. Nairn   +2 more
openaire   +3 more sources

Direct effects of sex steroids on prolactin release at the anterior pituitary level: interactions with dopamine, thyrotropin-releasing hormone, and isobutylmethylxanthine.

Endocrinology, 1982
When present alone for 4 or 8 days, 5 alpha-dihydrotestosterone (DHT) or the pure progestin R5020 (17,21-dimethyl-19-nor-4,9-pregnadiene-3,20-dione) inhibits spontaneous PRL release by 33--50% in rat anterior pituitary cells in primary culture.
Vincent Giguère, Helene Meunier, Raymonde Veilleux, F. Labrie   +3 more
semanticscholar   +1 more source

ChemInform Abstract: SYNTH. VON 17‐ACYLOXY‐3,5‐PREGNADIEN‐20‐ON‐DERIVATEN

Chemischer Informationsdienst. Organische Chemie, 1971
AbstractDurch selektive Reduktion mit Natriumborhydrid in Aceton in Gegenwart von Phosphormolybdänsäure werden die 3‐Hydroxy‐Derivate (II) und (V) erhalten, die durch Dehydratisierung die Pregnadien‐20‐on‐Derivate (III), (IV) und (Vii) liefern.
openaire   +2 more sources

Steroid 5α-Reductase Inhibitors

, 2003
The objective of this study is to synthesize new steroidal compounds based on the progesterone skeleton with a high inhibitory activity for the enzyme 5α-reductase.
E. Flores, E. Bratoeff, M. Cabeza, E. Ramírez, A. Quiroz, I. Heuze   +5 more
semanticscholar   +1 more source