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New steroidal anti-inflammatory antedrugs: Methyl 3,20-dioxo-9α-fluoro-11β,17α,21-trihydroxy-1,4-pregnadiene-16α-carboxylate and methyl 21-acetyloxy-3,20-dioxo-11β,17α-dihydroxy-9α-fluoro-1,4-pregnadiene-16α-carboxylate

Steroids, 1997
Focused efforts have been made to increase local-to-systemic activity ratios of potent anti-inflammatory steroids for local and/or topical applications. The approach taken in the present investigation is based upon the concept of "antedrug," defined as a locally active compound that exerts its action at the application site but rapidly undergoes a ...
Ann S. Heiman +3 more
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New corticoid 3-(2′-chloroethoxy)-6-formyl-9α-fluoro-δ3,5-pregnadien derivatives in experimental allergy

European Journal of Pharmacology, 1968
Abstract The anti-anaphylactic activity of some new synthetic corticoids in comparison to other known steroids was studied in several animal species. This class of compounds was shown to be particularly active in protecting mice against fatal anaphylactic shock.
G B, Fregnan, G K, Suchowsky
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Crystal structures of 4,11-pregnadiene-3,20-dione and 21-methyl-20-oxa-4-pregnene-3,20-dione

Journal of Chemical Crystallography, 1996
The structures of the title compounds were solved by direct methods and refined by anisotropic full-matrix least-squares methods. 4,11-Pregnadiene-3,20-dione, C21H28O2(1) crystallizes in the monoclinic space groupP21 (Z=2). The unit cell parametersa, b, c (A), and β (°) were: 12.319(2), 7.700(2), 9.717(2), 109.41(2).
Zdzisław Gałdecki +5 more
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Synthesis of 3-(2′-chloroethoxy)-6-formyl-Δ3,5-pregnadienes. A new class of highly active anti-inflammatory corticosteroids