Advanced Science, EarlyView.We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim +6 more
wiley +1 more source
Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs
Advanced Science, EarlyView.Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou +22 more
wiley +1 more source
Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease
Advanced Science, EarlyView.ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan +17 more
wiley +1 more source
Improving the reproductive performance of the Muturu breed of cattle in Nigeria using modified Ovsynch and progesterone synchronization protocol : a thesis presented in partial fulfilment of the requirement for the degree of Master of Science in Animal Science, Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand [PDF]
, 2017 The Ovsynch protocol has been used in cattle to synchronize ovulation and facilitate fixed-time AI (FTAI) but its efficacy has not been evaluated in the Nigerian Muturu breed of B. indicus cattle. The effects of a modified Ovsynch protocol (modified by
Obianwuna, Uchechukwu
core
Editorial: Pathogens and Pregnancy Failure in Domestic Animals [PDF]
Frontiers in Veterinary Science, 2022 openaire +3 more sources
Advanced Science, EarlyView.DOT1L as a central epigenetic regulator of EndoMT and pulmonary fibrosis. Acting as an early epigenetic switch, it translates TGFβ–SMAD signaling into H3K79me2‐mediated chromatin remodeling, selectively activates fibrosis‐related genes, and primes ECs for rapid mesenchymal transition.
Yaofeng Wang +11 more
wiley +1 more source
BMC Pregnancy and ChildbirthBackground Insufficient protein intake decreases serum free amino acid (FAA) concentrations and worse whole-body nutritional status, leading to poor pregnancy outcomes.
Takuya Shibasaki +9 more
doaj +1 more source
Deciphering decidual leukocyte traffic with serial intravascular staining
Frontiers in ImmunologyThe decidual immunome is dynamic, dramatically changing its composition across gestation. Early pregnancy is dominated by decidual NK cells, with a shift towards T cells later in pregnancy.
Jessica Vazquez +14 more
doaj +1 more source
Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain
Advanced Science, EarlyView.This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao +7 more
wiley +1 more source
Interventions of Iranian Traditional Medicine for Constipation During Pregnancy
Journal of Medicinal Plants, 2015 Background: Constipation is a common complaint during pregnancy. Iranian Traditional Medicine (ITM) has some recommendations for this complaint. Objective: In this study, interventions of constipation in pregnancy have been presented and their efficacy ...
F Hashem Dabaghian +3 more
doaj