Results 51 to 60 of about 473,012 (312)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Effects of Vitamin and Mineral Supplementation During Gestation in Beef Heifers on Immunoglobulin Concentrations in Colostrum and Immune Responses in Naturally and Artificially Reared Calves

Veterinary Sciences
Two experiments assessed the effects of providing a vitamin and mineral supplement to gestating beef heifers on concentrations of immunoglobulins (Ig) in colostrum and calf serum 24 h after feeding maternal colostrum (Exp.
Jennifer L. Hurlbert, Friederike Baumgaertner, Kerri A. Bochantin-Winders, Isabella M. Jurgens, Kevin K. Sedivec, Carl R. Dahlen   +5 more
doaj   +1 more source

Effects of extended grazing during mid, late or throughout pregnancy, and winter shearing of housed ewes, on ewe and lamb performance [PDF]

, 2007
peer-reviewedA flock of March-lambing ewes was used to evaluate the effects of (i) extended (deferred, winter) grazing of pasture during mid, late or throughout pregnancy, and (ii) winter shearing of ewes housed during mid and late pregnancy, on lamb ...
Flanagan, S., Hanrahan, James P, Keady, Tim   +2 more
core  

Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort [PDF]

, 2013
Data from epidemiological and animal model studies suggest that nutrition during pregnancy may affect the health status of subsequent generations. These transgenerational effects are now being explained by disruptions at the level of the epigenetic ...
A Kerjean, A Murrell, A Soubry, AD Stein, Adelheid Soubry, Amy Murtha, AP Feinberg, Autumn Bernal, BE Levin, BR Carone, BT Heijmans, C Gemma, C Gicquel, C Hoyo, C Hoyo, Cathrine Hoyo, CC Boissonnas, DC Dolinoy, DC Dolinoy, DJ Barker, Frances Wang, G Kaati, GA Dunn, GP Ravelli, H Boerschmann, H Cui, H Cui, H Cui, J Baker, J Frystyk, JA McKay, Joanne Kurtzberg, Joellen M Schildkraut, JS Dyer, KJ Stothard, LM McCowan, M Braunschweig, M Cruz-Correa, M Ollikainen, ME Pembrey, ME Pembrey, MJ Steenman, MJ Sullivan, Q Wu, R Barres, R Figueroa-Colon, R Loomba, RA Waterland, RA Waterland, RA Waterland, Randy L Jirtle, RC Painter, RC Painter, RL Jirtle, RP Steegers-Theunissen, S Honda, S Katari, S Pathak, SA Tanumihardjo, SD McDonald, SF Ng, SK Murphy, SK Murphy, SK Murphy, SS Du Plessis, Susan K Murphy, W Chao, Z Huang, Zhiqing Huang   +68 more
core   +3 more sources

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Early Gestational Hepatic Lipidomic Profiles Are Modulated by One-Carbon Metabolite Supplementation and Nutrient Restriction in Beef Heifers and Fetuses

Metabolites
Background: Maternal nutrition during early gestation induces metabolic adaptations that support maternal health and fetal development. This study evaluated the effects of maternal one-carbon metabolite (OCM: methionine, choline, folate, and vitamin B12)
Kazi Sarjana Safain, Matthew S. Crouse, Jessica G. Syring, Yssi L. Entzie, Layla E. King, Alison K. Ward, Lawrence P. Reynolds, Pawel P. Borowicz, Carl R. Dahlen, Kendall C. Swanson, Joel S. Caton   +10 more
doaj   +1 more source

Metabolic programming in pregnancy: studies in animal models [PDF]

Genes & Nutrition, 2007
Epidemiological studies of many large populations indicate that non-communicable diseases in adulthood are related to factors in fetal life or during infancy [1]. Low birthweight or disproportion at birth are associated with increased risk of cardiovascular disease and type-II diabetes.
openaire   +2 more sources

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

The Interplay of One-Carbon Metabolism, Mitochondrial Function, and Developmental Programming in Ruminant Livestock

Journal of Developmental Biology
Maternal nutrition during gestation profoundly influences fetal growth, organogenesis, and long-term offspring performance through developmental programming.
Kazi Sarjana Safain, Kendall C. Swanson, Joel S. Caton   +2 more
doaj   +1 more source

Mapping the effects of pregnancy on resting state brain activity, white matter microstructure, neural metabolite concentrations and grey matter architecture

Nature Communications, 2022
Animal studies have shown that pregnancy is associated with unique changes in the mammalian brain and behaviour, although pregnancy-associated changes in the human brain are less well studied.
Elseline Hoekzema, Henk van Steenbergen, Milou Straathof, Arlette Beekmans, Inga Marie Freund, Petra J. W. Pouwels, Eveline A. Crone   +6 more
doaj   +1 more source