Results 31 to 40 of about 334,845 (260)

Estimating the costs associated with the implementation of a best practice model of care for recurrent miscarriage clinics in Ireland: a cost analysis [version 1; peer review: 1 approved, 2 approved with reservations]

HRB Open Research, 2022
Background  Recurrent miscarriage (RM) affects 1%-5% of the reproductive age population. Given increasing calls for dedicated recurrent miscarriage clinics (RMC), decision makers will require data on the resultant budgetary implications.
Keelin O'Donoghue, Caragh Flannery, Paddy Gillespie, Lee-Ann Burke   +3 more
doaj   +1 more source

A protocol for a systematic review of clinical practice guidelines for the antenatal management of dichorionic diamniotic twin pregnancy [version 1; peer review: 2 approved]

HRB Open Research, 2021
Overview: The protocol outlines the process designed to systematically review clinical practice guidelines (CPGs), addressing the antenatal management of dichorionic diamniotic (DCDA) twin pregnancies.
Caroline O'Connor, Keelin O'Donoghue, Sara Leitao   +2 more
doaj   +1 more source

The experiences of men following recurrent miscarriage in an Irish tertiary hospital: A qualitative analysis

Health Expectations, 2022
Introduction Miscarriage is one of the most common complications of pregnancy, and recurrent miscarriage affects approximately 1% of couples. The psychological impact of early pregnancy loss on women has been well documented in the literature; however ...
Tommy Harty, Maria Trench, Orla Keegan, Keelin O'Donoghue, Daniel Nuzum   +4 more
doaj   +1 more source

Pregnancy and infant loss: a survey of families’ experiences in Ontario Canada

BMC Pregnancy and Childbirth, 2019
Background Pregnancy and infant loss has a pervasive impact on families, health systems, and communities. During and after loss, compassionate, individualized, and skilled support from professionals and organizations is important, but often lacking ...
Jo Watson, Anne Simmonds, Michelle La Fontaine, Megan E. Fockler   +3 more
doaj   +1 more source

Increased Risk of Sarcomas in Children With Congenital Anomalies: Findings From the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Registry Linkage Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated. Procedure We
Russ Wolters, Ji Yun Tark, Tiffany M. Chambers, Tania A. Desrosiers, Michael E. Scheurer, Charles Shumate, Wendy N. Nembhard, Mahsa M. Yazdy, Eirini Nestoridi, Amanda E. Janitz, Jean Paul Tanner, Russell S. Kirby, Jason L. Salemi, Yao Yu, Chad D. Huff, Sharon E. Plon, Philip J. Lupo, Jeremy M. Schraw   +17 more
wiley   +1 more source

Intrapartum fetal deaths and unexpected neonatal deaths in the Republic of Ireland: 2011 – 2014; a descriptive study

BMC Pregnancy and Childbirth, 2018
Background Intrapartum fetal death, the death of a fetus during labour, is a tragic outcome of pregnancy. The intrapartum death rate of a country is reflective of the care received by mothers and babies in labour and it is through analysing these cases ...
K. McNamara, K. O’Donoghue, R. A. Greene   +2 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Current Irish medicolegal landscape: an unsustainable trajectory

BMJ Open Quality, 2023
The number of outstanding clinical claims that are yet to be resolved as well as their associated estimated costs are at a record high in Ireland. By the end of 2022, the Irish government face 3875 active clinical claims which are expected to cost €3.85 ...
Keelin O'Donoghue, Clara Forrest, Dearbhaile C Collins, Seamus O'Reilly   +3 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Genomics of pregnancy loss

Journal of Assisted Reproduction and Genetics
Pregnancy loss is the most common obstetric complication occurring in almost 15% of pregnancies. Of the examined products of conception (POC), approximately 60% of pregnancy losses result from chromosomal abnormalities and copy number variations (CNVs) in embryos, but genetic etiologies of euploid pregnancy loss remain largely unexplained.
Tatiana V. Nikitina, Elizaveta A. Fonova, Igor N. Lebedev   +2 more
openaire   +3 more sources