Results 51 to 60 of about 3,610,785 (264)

Selected non-somatic risk factors for pregnancy loss in patients with abnormal early pregnancy [PDF]

, 2015
Introduction and objective Spontaneous abortion constitutes one of the most frequent complication of human pregnancy. Despite intensive research efforts undertaken to date, the etiopathogenesis of early pregnancy loss has not been fully elucidated.
Paszkowski, M., Maciej Paszkowski, Paszkowski, T., Wozniak, S., Szkodziak, P., Piotr Czuczwar, Monika Paszkowska, Patyra, K., Sławomir Woźniak, Paszkowska, M., Krzysztof Patyra, Tomasz Paszkowski, Czuczwar, P., Piotr Szkodziak   +13 more
core   +2 more sources

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Recurrent Miscarriage and Infertility Services and Supports: A Qualitative Study of Views and Experiences in the Republic of Ireland

Health Expectations
Background Recurrent miscarriage (RM) and infertility are separately associated with psychological distress and adverse pregnancy outcomes. The dual experience is devastating for women/couples but is not considered in clinical guidance for RM or ...
Laura Aoife Linehan, Marita Hennessy, Keelin O'Donoghue   +2 more
doaj   +1 more source

Miscarriage hospitalisations: a national population-based study of incidence and outcomes, 2005–2016

Reproductive Health, 2019
Background Early miscarriage is one of the most common obstetric causes of maternal morbidity early in pregnancy. However, data concerning non-fatal complications among hospitalisations for early miscarriage are lacking.
Indra San Lazaro Campillo, Sarah Meaney, Keelin O’Donoghue, Paul Corcoran   +3 more
doaj   +1 more source

Clinical practice guidelines for the antenatal management of dichorionic diamniotic twin pregnancies: a systematic review

BMC Pregnancy and Childbirth, 2023
Objective This review aimed to identify guidelines with recommendations applicable to the antenatal management of dichorionic diamniotic twin pregnancies within high-income countries, appraise their methodological quality, and discuss the similarities ...
Caroline O’Connor, Emily O’Connor, Sara Leitao, Shauna Barrett, Keelin O’Donoghue   +4 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Involving Knowledge Users in Health Services Research: Collective Reflections and Learning From a National Evaluation of Recurrent Miscarriage Services

Health Expectations
Introduction Involving knowledge users in research can facilitate the translation of evidence into policy and practice. How to best involve and support various types of knowledge users, including patient and public involvement contributors, in research ...
Marita Hennessy, Rebecca Dennehy, Hannah O'Leary, Keelin O'Donoghue, RE:CURRENT Research Advisory Group   +4 more
doaj   +1 more source

Dysbiosis of the Human Oral Microbiome During the Menstrual Cycle and Vulnerability to the External Exposures of Smoking and Dietary Sugar

Frontiers in Cellular and Infection Microbiology, 2021
Physiological hormonal fluctuations exert endogenous pressures on the structure and function of the human microbiome. As such, the menstrual cycle may selectively disrupt the homeostasis of the resident oral microbiome, thus compromising oral health ...
Nagihan Bostanci, Maria Christine Krog, Maria Christine Krog, Luisa W. Hugerth, Luisa W. Hugerth, Zahra Bashir, Zahra Bashir, Emma Fransson, Emma Fransson, Fredrik Boulund, Fredrik Boulund, Georgios N. Belibasakis, Kristin Wannerberger, Lars Engstrand, Lars Engstrand, Henriette Svarre Nielsen, Henriette Svarre Nielsen, Henriette Svarre Nielsen, Ina Schuppe-Koistinen, Ina Schuppe-Koistinen   +19 more
doaj   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Views of knowledge users on recurrent miscarriage services and supports in the Republic of Ireland: a qualitative interview study

BMJ Open
Objectives Women and men/partners who experience miscarriage often report poor care experiences within health services around the time of miscarriage and beyond; less is known about recurrent miscarriage (RM) care.
Karen Matvienko-Sikar, Marita Hennessy, Keelin O’Donoghue, Rebecca Dennehy, Con Lucey, Ria O’Sullivan-Lago, Jennifer Uí Dhúbhgáin   +6 more
doaj   +1 more source