Results 71 to 80 of about 3,610,785 (264)

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Psychosocial supports for staff in maternity hospitals and units following adverse events: a mapping study in the Republic of Ireland

BMC Health Services Research
Background Maternity staff commonly experience adverse events within their roles. Such events can have a profound impact, with a range of psychological impacts reported. Many maternity staff, however, report receiving inadequate support.
Marita Hennessy, Keelin O’Donoghue
doaj   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

Bridging the gap between pregnancy loss research and policy and practice: insights from a qualitative survey with knowledge users

Health Research Policy and Systems
Background The loss of a pregnancy or the death of baby around the time of their birth can have profound impacts on parents, families and staff involved.
Marita Hennessy, Keelin O’Donoghue
doaj   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

The role of Coroners in perinatal death investigation in high-income countries: a scoping review

Journal of Perinatal Medicine
The primary role of a Coroner is to investigate unexpected deaths. However, the global literature on Coroner’s role in perinatal death cases is limited.
Shetty Varsha N., O’Donoghue Keelin, Donnelly Mary, Leitao Sara   +3 more
doaj   +1 more source

Pre-pregnancy complications - associated factors and wellbeing in early pregnancy: a Swedish cohort study

, 2023
Background: Many couples experience difficulties to become pregnant or carry a pregnancy to term due to unknown causes. Here we define pre-pregnancy complications as having prior recurrent pregnancy loss, prior late miscarriages, time to pregnancy more ...
Du, Juan,, Schuppe-Koistinen, Ina,, Gudnadottir, U, Gudnadottir, Unnur, Gudnadottir, Unnur,, Hugerth, LWW, Du, J,, Engstrand, Lars, Itzel, Eva Wiberg,, Hugerth, Luisa W. W., Brusselaers, Nele, Engstrand, L,, Brusselaers, N,, Hugerth, Luisa W. W.,, Fransson, Emma,, Fransson, E,, Itzel, EW, Du, Juan, Schuppe-Koistinen, Ina, Engstrand, Lars,, Brusselaers, Nele,, Schuppe-Koistinen, I, Itzel, Eva Wiberg, Fransson, Emma, Juan Du, Emma Fransson, Eva Wiberg Itzel, Nele Brusselaers, Hugerth, Luisa W.W., Lars Engstrand, Ina Schuppe-Koistinen, Wiberg Itzel, Eva, Unnur Gudnadottir, Luisa W. Hugerth, Hugerth, Luisa W.   +34 more
core   +1 more source

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source

'Head-hunting' (or grief management) on Teesside: Pregnancy loss and the use of counselling as a ritual in the resolution of consequential grief [PDF]

, 2001
This anthropological thesis is based on an evaluation carried out at South Cleveland Hospital on Teesside, where midwives offer counselling to bereaved parents following pregnancy loss.
Brydon, Christine
core  

Baseline Neuroinflammation Stratifies TSPO‐PET Response to Disease‐Modifying Therapy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch, Markus Matilainen, Giulia N. Baldrighi, Marjo Nylund, Maija Saraste, Laura Airas   +5 more
wiley   +1 more source