Results 41 to 50 of about 770,380 (355)

Intrapartum fetal deaths and unexpected neonatal deaths in the Republic of Ireland: 2011 – 2014; a descriptive study

BMC Pregnancy and Childbirth, 2018
Background Intrapartum fetal death, the death of a fetus during labour, is a tragic outcome of pregnancy. The intrapartum death rate of a country is reflective of the care received by mothers and babies in labour and it is through analysing these cases ...
K. McNamara, K. O’Donoghue, R. A. Greene   +2 more
doaj   +1 more source

Current Irish medicolegal landscape: an unsustainable trajectory

BMJ Open Quality, 2023
The number of outstanding clinical claims that are yet to be resolved as well as their associated estimated costs are at a record high in Ireland. By the end of 2022, the Irish government face 3875 active clinical claims which are expected to cost €3.85 ...
Keelin O'Donoghue, Clara Forrest, Dearbhaile C Collins, Seamus O'Reilly   +3 more
doaj   +1 more source

Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack, A. Carolina Tufino, Mohd Azrin Jamalruddin, Sreya Dey, Yinghong Pan, Elina Mukherjee, Jessica D. Daley, Julia Meade, Mahmoud Aarabi, Lisa Maurer, James Cooper, Kara A. Bernstein, Kelly M. Bailey   +12 more
wiley   +1 more source

Significant correlation of angiotensin converting enzyme and glycoprotein IIIa genes polymorphisms with unexplained recurrent pregnancy loss in north of Iran [PDF]

, 2016
Background: Spontaneous abortion is considered as the most complex problem during pregnancy. Thrombophilia is resumed as a cause of recurrent pregnancy loss (RPL). Glycoprotein IIIa (GPIIIa) gene is involved in thrombosis and abortion.
Farazmandfar, T., Fazelnia, S., Hashemi-Soteh, S.M.B.   +2 more
core   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Dysbiosis of the Human Oral Microbiome During the Menstrual Cycle and Vulnerability to the External Exposures of Smoking and Dietary Sugar

Frontiers in Cellular and Infection Microbiology, 2021
Physiological hormonal fluctuations exert endogenous pressures on the structure and function of the human microbiome. As such, the menstrual cycle may selectively disrupt the homeostasis of the resident oral microbiome, thus compromising oral health ...
Nagihan Bostanci, Maria Christine Krog, Maria Christine Krog, Luisa W. Hugerth, Luisa W. Hugerth, Zahra Bashir, Zahra Bashir, Emma Fransson, Emma Fransson, Fredrik Boulund, Fredrik Boulund, Georgios N. Belibasakis, Kristin Wannerberger, Lars Engstrand, Lars Engstrand, Henriette Svarre Nielsen, Henriette Svarre Nielsen, Henriette Svarre Nielsen, Ina Schuppe-Koistinen, Ina Schuppe-Koistinen   +19 more
doaj   +1 more source

The GOAL study: a prospective examination of the impact of factor V Leiden and ABO(H) blood groups on haemorrhagic and thrombotic pregnancy outcomes [PDF]

, 2008
Factor V Leiden (FVL) and ABO(H) blood groups are the common influences on haemostasis and retrospective studies have linked FVL with pregnancy complications. However, only one sizeable prospective examination has taken place.
Carstairs V., Cashner K., Catalano P., Clark P., Escuriola Ettingshausen C., Gill A., Harlap S., Lindqvist P., Lindqvist P.G., May D., Morris R., Neerhof M., Preston A., Robert A., Samueloff A., Sezik M., South J., van ‘t Veer C.   +17 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Miscarriage hospitalisations: a national population-based study of incidence and outcomes, 2005–2016

Reproductive Health, 2019
Background Early miscarriage is one of the most common obstetric causes of maternal morbidity early in pregnancy. However, data concerning non-fatal complications among hospitalisations for early miscarriage are lacking.
Indra San Lazaro Campillo, Sarah Meaney, Keelin O’Donoghue, Paul Corcoran   +3 more
doaj   +1 more source

Clinical practice guidelines for the antenatal management of dichorionic diamniotic twin pregnancies: a systematic review

BMC Pregnancy and Childbirth, 2023
Objective This review aimed to identify guidelines with recommendations applicable to the antenatal management of dichorionic diamniotic twin pregnancies within high-income countries, appraise their methodological quality, and discuss the similarities ...
Caroline O’Connor, Emily O’Connor, Sara Leitao, Shauna Barrett, Keelin O’Donoghue   +4 more
doaj   +1 more source