Results 241 to 250 of about 1,077,944 (364)

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Management of patients with endometriosis and infertility: laparoscopic treatment and spontaneous pregnancy rate. [PDF]

JBRA Assist Reprod
Rodríguez Y, Grasso E, Tessari L, Perotti F, Irigoyen M, Cattaneo A, Martínez AG, Ramhorst R, Gnocchi D.   +8 more
europepmc   +1 more source

Novel Bedding Material Results in Poor Pregnancy Rate with CD-1 Female Mice Used as Fosters for Producing Transgenic Mice

, 2017
Jussi Helppi, Ronald Naumann, Marianne Asikainen, J. Mononen, Oliver Zierau   +4 more
openalex   +2 more sources

The effect of a thin late proliferative endometirum on pregnancy rates following frozen embryo transfer in the modern in vitro fertilization (IVF) era [PDF]

, 2008
J.H. Check, J.K. Choe, C. Dietterich, J. Amui, D. Brasile   +4 more
openalex   +1 more source

The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia

Advanced Science, EarlyView.
The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo, Seong‐Gook Kang, Kunlun Huang, Tao Tong   +3 more
wiley   +1 more source

A Comprehensive Comparison of PICSI and ICSI Techniques Through a Triple-Blinded Trial: Effects on Embryo Quality, Cumulative Pregnancy Rate, and Live Birth Rate. [PDF]

Biomedicines
Alegre L, Carrión-Sisternas L, Bori L, Hervás I, Remohí J, Garrido N, Meseguer M.   +6 more
europepmc   +1 more source

Magnetically‐Induced Suppression of Oxidative Stress Prevents Venous Thrombosis

Advanced Science, EarlyView.
Venous thromboembolism (VTE) remains a leading cause of cardiovascular mortality. This study demonstrates that static magnetic fields (SMF) offer a novel non‐pharmacological intervention against VTE by mitigating endothelial oxidative stress. Mechanistically, SMF elevates intracellular Ca2+, boosts ATP production, and suppresses NOX4‐mediated ROS ...
Nana Zhang, Yirong An, Shiran Tao, Shenao Qu, Minge Wu, Guantong Fang, Ziqing Chen, Weilun Song, Haoze Leng, Rongqian Wu, Yi Lyu, Xiaoli Liu, Dinghui Dong   +12 more
wiley   +1 more source

Intra-ovarian injection of autologous menstrual blood-derived-mesenchymal stromal cells: a safe and promising method to improve pregnancy rate in poor ovarian responders. [PDF]

Stem Cell Res Ther
Zafardoust S, Didar H, Ganagard MG, Tavakoli M, Arefi S, Arjmandinaloo S, Fathi-Kazerooni M.   +6 more
europepmc   +1 more source

The effects of intramuscular or intravenous injections of gonadotropin releasing hormone at fixed-time artificial insemination on pregnancy rates of Bos indicus beef cows [PDF]

, 2014
Danilo Demeterco, Darren D Henry, Vitor R G Mercadante, G. C. Lamb, Francisco Romano Gaievski, Bruno Weiss, Gustavo Nascimento Turbay, Márcio Saporski Segui, Romildo Romualdo Weiss, Melina Andreia Formighieri Betiol, Luiz Ernandes Kozicki   +10 more
openalex   +1 more source

Integrated ERK‐PKA‐YAP/TAZ‐SHH Signaling Orchestrates Cortical Radial Glia Identity and Lineage Diversification

Advanced Science, EarlyView.
This study shows that ERK/PKA upregulation in mammalian cortical radial glia (RGs) sustains neurogenesis and suppresses gliogenesis. YAP/TAZ activation promotes ependymal cell formation, while enhanced SHH‐SMO signaling induces astrocyte, oligodendrocytes, and olfactory bulb interneuron generation.
Zhuangzhi Zhang, Zhejun Xu, Tongye Fu, Jialin Li, Feihong Yang, Chuannan Yang, Wenhui Zheng, Zizhuo Sha, Yanjing Gao, Mengge Sun, Zhenmeiyu Li, Jing Ding, Xiaosu Li, Zhengang Yang   +13 more
wiley   +1 more source