Results 71 to 80 of about 661,225 (269)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Pregnant smokers: Room for improvement [PDF]

Clinical Health Promotion - Research and Best Practice for patients, staff and community, 2015
Contact: Hanne Tonnesen Hanne.Tonnesen@regionh.dk Overall, the effect of smoking cessation intervention for pregnant women is as low as 6% (5). The more effective programmes include incitements (5) and intensive interventions over 6 weeks (6). The 6 weeks Gold Standard Programme is implemented as the standard intervention in Denmark and has recently ...
openaire   +2 more sources

Congenital defects of development – contribution to children’s morbidity and disability, approaches to prevention

Репродуктивная эндокринология, 2018
One of the most important reasons for the formation of structural anomalies during the prenatal period is the lack of nutrients in the diet of a pregnant woman, such as folates, iodine and docosahexaenoic acid.
О. И. Пикуза, А. М. Закирова, Е. В. Волянюк, Ф. Ф. Ризванова   +3 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Exploring Experiences with “321” Model Management for High-Risk Pregnancy: A Qualitative Study

Maternal-Fetal Medicine, 2023
Wen Sun, Peili Du, Lin Yu, Xiaoyi Wang, Fang He, Jingsi Chen, Chunhong Su, Dunjin Chen   +7 more
doaj   +1 more source

HIV risk perception and associated factors among pregnant and breastfeeding women in Zambia: implications for PrEP uptake in antenatal and postnatal settings

Frontiers in Reproductive Health
IntroductionHIV risk perception is seen as a key motivation for individuals to use biomedical HIV prevention interventions, including pre-exposure prophylaxis (PrEP).
Twaambo Euphemia Hamoonga, Wilbroad Mutale, Karen Hampanda, Benjamin H. Chi   +3 more
doaj   +1 more source

The Epidemiology, Associated Factors and Bacterial Profile of Asymptomatic Bacteriuria in Pregnant Women: A Retrospective Chart Review Study in Saudi Arabia

International Journal of Women's Health, 2022
Nouf A AlShamlan,1 Reem S AlOmar,1 Roba Aldossary,2 Maha Alahmari,2 Asma Alghamdi,2 Mawaddah AlGhamdi,2 Najla Alkanaan,2 Abdullah H AlReedy,1 Amani S AlOtaibi,3 Nada S Alghamdi4 1Department of Family and Community Medicine, College of Medicine, Imam ...
AlShamlan NA, AlOmar RS, Aldossary R, Alahmari M, Alghamdi A, AlGhamdi M, Alkanaan N, AlReedy AH, AlOtaibi AS, Alghamdi NS   +9 more
doaj  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source