Results 91 to 100 of about 1,195,031 (303)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Fair inclusion of pregnant women in clinical trials: an integrated scientific and ethical approach

Trials, 2018
Background Since pregnant women are severely underrepresented in clinical research, many take the position that the exclusion of pregnant women from research must be justified unless there are compelling “scientific reasons” for their exclusion. However,
Rieke van der Graaf, Indira S. E. van der Zande, Hester M. den Ruijter, Martijn A. Oudijk, Johannes J. M. van Delden, Katrien Oude Rengerink, Rolf H. H. Groenwold   +6 more
doaj   +1 more source

Offering weight management support to pregnant women with high body mass index: A qualitative study with midwives [PDF]

, 2019
Objective: The prevalence of pregnant women with high body mass index is increasing worldwide. High body mass index is associated with health risks for mother and baby and supporting healthy gestational weight gain is important.
Allen-Walker, Atkinson, Atkinson, Braun, Christenson, de Jersey, DeJoy, Dencker, Ekman, Furness, Haby, Haby, Hasted, Heslehurst, Heslehurst, Institute of Medicine, Knight-Agarwal, Lindhardt, Lindqvist, Marchi, McCann, McCann, McGiveron, McIntyre, Mulherin, Nyman, Olander, Olander, Olander, Patel, Petrov Fieril, Poston, Simmons, Small, Wennberg   +34 more
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Treating thyrotoxicosis in pregnant or potentially pregnant women

BMJ, 1999
Thyrotoxicosis affects up to 0.2% of pregnant women.1 If left untreated it is associated with increased fetal mortality and morbidity.2 Treatment is with antithyroid drugs such as propylthiouracil or carbimazole, with β blockers reserved for presurgical treatment and immediate control of severe thyrotoxic symptoms. Considerable concern exists, however,
M J, O'Doherty, P R, McElhatton, S H, Thomas   +2 more
openaire   +3 more sources

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Estimation of Salivary Candida Count Among Pregnant and Non-Pregnant Women

Journal of Islamic International Medical College
Objective: Comparison of Candida count in the saliva of pregnant and non-pregnant women to determine how much salivary Candida count increases in pregnancy as compared to non-pregnant women. Study Design: Cross-sectional study.
Fareeha Aleem, Tehmina Munir, Afia Shafiq, Farhat Abbas Bhatti, Syeda Fatima Babar, Faizan Hamid
doaj   +1 more source

QT Interval in Pregnant and Non-pregnant Women.

Emergency (Tehran, Iran), 2014
Prolongation of QT interval might result in dangerous cardiac arrhythmias, including Torsades de Pointes (TdP), consequently leading to syncope or death. A limited number of studies carried out in this respect to date have shown that QT interval might increase during pregnancy. On the other hand, it has been shown that each pregnancy might result in an
Zamani, Majid, Esmailian, Mehrdad, Yoosefian, Zahra   +2 more
openaire   +4 more sources

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source