Results 81 to 90 of about 304,421 (272)

The Subjectivity of Effective History and the Suppressed Husserlian Elements in Gadamer’s Philosophical Hermeneutics [PDF]

open access: yes, 2007
This essay makes two claims. The first, exegetical, point shows that there are Husserlian elements in Gadamer’s hermeneutics that are usually overlooked.
Luft, Sebastian
core   +1 more source

A Radical Revolution in Thought: Frederick Douglass on the Slave’s Perspective on Republican Freedom [PDF]

open access: yes, 2020
While the image of the slave as the antithesis of the freeman is central to republican freedom, it is striking to note that slaves themselves have not contributed to how this condition is understood.
Coffee, Alan M. S. J.
core  

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Conciliar lo laboral y doméstico: un reto para la sociedad cubana actual / Reconciling the Work and the Household Domains: a Challenge for Today’s Cuban Society

open access: yesAsparkía, 2009
RESUMEN: Se analiza con elementos concretos cómo en Cuba a partir del primero de enero de 1959 la situación de la sociedad cubana cambió profundamente y en particular la de la mujer.
Maribel Almaguer Rondón
doaj  

Childhood stuttering

open access: yesListy klinicke logopedie, 2021
The article gives a historical overview and the state of the art concerning childhood stuttering. It deals with the well-established and recommended methods of treating stuttering and of advising parents.
Patricia Sandrieser
doaj  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

innovation, employee control, efficiency, resistance to social change, dirty work

open access: yesBulletin of the Transilvania University of Braşov: Series VII: Social Sciences, Law
This article presents the theoretical framework and the results of a research conducted in a brewery with respect to the concept of gender discrimination. The main objective of the research is to identify gender inequalities and
Ada Ioana Dobrescu
doaj   +1 more source

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