Results 41 to 50 of about 883,299 (307)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

A Simplified Chemical Reactor Network Approach for Aeroengine Combustion Chamber Modeling and Preliminary Design

Aerospace, 2023
In a time when low emission solutions and technologies are of utmost importance regarding the sustainability of the aviation sector, this publication introduces a reduced-order physics-based model for combustion chambers of aeroengines, which is capable ...
Sergios Villette, Dimitris Adam, Alexios Alexiou, Nikolaos Aretakis, Konstantinos Mathioudakis   +4 more
doaj   +1 more source

Preliminary design of SALTO, the Belgian adaptive optics demonstrator [PDF]

, 2018
SALTO is a Belgian project aiming to build a complete 1 m telescope demonstrator including a single-conjugated adaptive optics (AO) system together with a Rayleigh laser guide star system.
Gilles Orban de Xivry, SPIE 2018, Danielle Vanhoenacker-Janvier, Lismont, Marjorie, Fabian Languy, Languy, Fabian, Vanhoenacker-Janvier, Danielle, Vincent Moreau, Absil, Olivier, Languy, F., Lismont, T., Orban De Xivry, Gilles, Marjorie Lismont, Olivier Absil, Orban de Xivry, G., Absil, O., Moreau, V., Moreau, Vincent   +17 more
core   +1 more source

Faint Traces of Social Impact in Design Ph.D.

, 2023
There is growing pressure to produce projects and graduates who can monitor, evaluate and plan for a positive social impact. This paper presents preliminary results and the methodology of a research project involving doctorate programmes in six ...
Nader Sayun, Michel, Hodson, Elise, Gulay, Emrecan   +2 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Design of a Low-Cost Easy-to-Fly STOL Ultralight Aircraft in Composite Material

Acta Polytechnica, 2005
The paper deals with the design of an aircraft, starting from a market survey, the conceptual design loop and the preliminary choice of dimensions, and leading to the detailed design of efficient high-lift systems and a low-drag fuselage shape ...
D. P. Coiro, A. de Marco, F. Nicolosi, N. Genito, S. Figliolia   +4 more
doaj  

Novel Aero-Engine Multi-Disciplinary Preliminary Design Optimization Framework Accounting for Dynamic System Operation and Aircraft Mission Performance

Aerospace, 2021
This paper presents a modular, flexible, extendable and fast-computational framework that implements a multidisciplinary, varying fidelity, multi-system approach for the conceptual and preliminary design of novel aero-engines.
Alexios Alexiou, Nikolaos Aretakis, Ioannis Kolias, Konstantinos Mathioudakis   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Artificial Intelligence for Developing Accurate Preliminary Cost Estimates for Composite Flooring Systems of Multi-Storey Buildings

Journal of Asian Architecture and Building Engineering, 2022
In a decision-making study, design alternatives are compared with respect to cost, performance, and reliability, and the best is selected. Often, due to the time constraints imposed by the design schedule and budget restrictions, the number of design ...
Hosam Elhegazy, Debaditya Chakraborty, Hazem Elzarka, Ahmed M. Ebid, Ibrahim M. Mahdi, Said Y. Aboul Haggag, Ibrahim Abdel Rashid   +6 more
doaj   +1 more source

Design expertise in public and social innovation [PDF]

, 2018
Over the past decade a new type of design practice has emerged that is aimed at addressing complex societal problems through public and social sector innovation.
van der Bijl-Brouwer, M, Malcolm, B, Bridget Malcolm, Mieke van der Bijl-Brouwer, van der Bijl-Brouwer, Mieke, Malcolm, Bridget   +5 more
core   +1 more source